Results 71 to 80 of about 3,042,639 (351)

Effect of stress ratio on the very high-cycle fatigue failure mechanism of TC4 titanium alloy

open access: yes工程科学学报, 2019
As technology has developed along with the increasing mechanical demands placed upon it, the need for fatigue exceeding 107 cycles or even longer for machines and components is necessary, not only for safety and reliability, but also for minimizing the ...
GAO Ning, LI Wei
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Effect of Stress Ratio on Fatigue Crack Growth Behavior of Ti-6Al-2Zr-1Mo-1V Alloy

open access: yesJournal of Aeronautical Materials, 2018
The fatigue crack growth behaviors of Ti-6.5Al-2Zr-1Mo-1V titanium alloy at different positive stress ratios (R = 0.1, 0.3 and 0.5) were investigated at room temperature.
JI Yingping, WU Sujun
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Compliance and stress sensitivity of spur gear teeth [PDF]

open access: yes, 1983
The magnitude and variation of tooth pair compliance with load position affects the dynamics and loading significantly, and the tooth root stressing per load varies significantly with load position.
Cornell, R. W.
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

An improved method for obtaining a normalized junction temperature for semiconductors: A concept [PDF]

open access: yes, 1973
Failure rate for given semiconductor device is simply determined by reading value of normalized junction temperature from printout for any given combination of ambient temperature, stress ratio, and maximum rated junction temperature, and obtaining ...
Trivedi, S. N.
core   +1 more source

Discrete dislocation dynamics simulations of dislocation-$\theta'$ precipitate interaction in Al-Cu alloys

open access: yes, 2018
The mechanisms of dislocation/precipitate interaction were studied by means of discrete dislocation dynamics within a multiscale approach. Simulations were carried out using the discrete continuous method in combination with a fast Fourier transform ...
Capolungo, L.   +5 more
core   +1 more source

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