MR‐Guidance of Gene Therapy for Brain Diseases: Moving From Palliative Treatment to Cures
ABSTRACT Regulatory bodies in the U.S. and Europe recently approved a gene therapy for aromatic L‐amino acid decarboxylase (AADC) deficiency, a rare neurologic disorder where a genetic mutation prevents dopamine production in the brain. Affected children fail to develop normal motor and cognitive functions.
Dalton H. Bermudez+2 more
wiley +1 more source
Calmodulin‐Sensitive and Calmodulin‐Insensitive Components of Adenylate Cyclase Activity in Rat Striatum Have Differential Responsiveness to Guanyl Nucleotides [PDF]
Glenn Treisman+2 more
openalex +1 more source
“MR Fingerprinting for Imaging Brain Hemodynamics and Oxygenation”
ABSTRACT Over the past decade, several studies have explored the potential of magnetic resonance fingerprinting (MRF) for the quantification of brain hemodynamics, oxygenation, and perfusion. Recent advances in simulation models and reconstruction frameworks have also significantly enhanced the accuracy of vascular parameter estimation.
T. Coudert+6 more
wiley +1 more source
Autoradiographic localization and biochemical characteristics of M1 and M2 muscarinic binding sites in the striatum of the cat, monkey, and human [PDF]
MA Nastuk, Ann M. Graybiel
openalex +1 more source
Mass spectrometry imaging of N‐linked glycans: Fundamentals and recent advances
Abstract With implications in several medical conditions, N‐linked glycosylation is one of the most important posttranslation modifications present in all living organisms. Due to their nontemplate synthesis, glycan structures are extraordinarily complex and require multiple analytical techniques for complete structural elucidation.
Tana V. Palomino, David C. Muddiman
wiley +1 more source
Direct demonstration of a correspondence between the dopamine islands and acetylcholinesterase patches in the developing striatum. [PDF]
Ann M. Graybiel+4 more
openalex +1 more source
Evidence for two functionally distinct subpopulations of neurons within the rat striatum [PDF]
ES Nisenbaum, WB Orr, TW Berger
openalex +1 more source