Results 191 to 200 of about 141,474 (306)
The activity of dopamine-stimulated adenylate cyclase from rat brain striatum is modulated by temperature and the bilayer-fluidizing agent, benzyl alcohol [PDF]
, 1982 Lindsey Needham, Miles D. Houslay
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Movement Disorders, EarlyView.Abstract Background Breakdown of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) in basal ganglia cells through hydrolysis of diesteric bonds, primarily by PDE10A and PDE1B, is essential for normal human movement. While biallelic loss‐of‐function variants in PDE10A are known to cause hyperkinetic movement disorders, the ...
Tomer Poleg +21 more
wiley +1 more source
Is the striatum involved in passive-avoidance behavior? A commentary [PDF]
, 1981 Stephen Polgar +2 more
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A Convergent Pathway for Stimulation‐Induced Dyskinesia Following Deep Brain Stimulation
Movement Disorders, EarlyView.Abstract Background Stimulation‐induced dyskinesias (SID) from deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus internus (GPi) are uncommon; however, they are increasingly recognized. Once considered transient and indicative of effective neuromodulation, SID are now seen as potential therapy‐limiting side effects, akin ...
Joshua K. Wong +4 more
wiley +1 more source
GLIAL AND NEURONAL ALTERATIONS IN THE CORPUS STRIATUM OF RATS WITH CCl4-INDUCED LIVER DISEASE
, 1977 Nils Henrik Diemer
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Movement Disorders, EarlyView.Abstract Traditionally, clinical trials of putative disease‐modifying therapies in Parkinson's disease have enrolled untreated patients at the earliest clinical stages of their disease. Due to a number of challenges inherent with this approach, there has been a recent move to a different study design, enrolling patients who are already taking “stable ...
M. Maral Mouradian +2 more
wiley +1 more source
Opioid inhibition of adenylate cyclase in the striatum and vas deferens of the rat [PDF]
, 1986 K. D. Bhoola, Sarah Pay
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Pregnenolone Reduces L‐Dopa‐Induced Dyskinesias in Female Parkinsonian Monkeys
Movement Disorders, EarlyView.Pregnenolone is the first neurosteroid synthesized from cholesterol in the brain. Ovariectomized female monkeys were tested as a model of women in menopause. They were lesioned with MPTP modeling Parkinson's disease and treated with levodopa (L‐dopa) to induce dyskinesias.
Mélanie Bourque +5 more
wiley +1 more source