Results 81 to 90 of about 141,474 (306)

Multisensory Integration in the Mouse Striatum [PDF]

Neuron, 2014
The basal ganglia are involved in sensorimotor functions and action selection, both of which require the integration of sensory information. In order to determine how such sensory inputs are integrated, we obtained whole-cell recordings in mouse dorsal striatum during presentation of tactile and visual stimuli.
Ramon Reig, Gilad Silberberg
openaire   +4 more sources

Brain‐Wide Spatiotemporally Distinct Traveling Waves Drive Anxiety‐Like Behaviors in Mice

Advanced Science, EarlyView.
J.Liu et al. reveal the complete propagation dynamics of cortical traveling waves, from local circuitry initiation to long‐range propagation, and identify their functional relevance in modulating anxiety‐like behaviors and underlying cellular neuroplasticity in mice.
Jiaming Liu, Jia‐Wen Mo, Xunda Wang, Yinuo Ma, Shile Tian, Qi Wang, Peng‐Li Kong, Ziqi An, Li Ding, Jing Ren, Cheng‐Lin Lu, Chuanjun Tong, Ed X. Wu, Qiu‐gen Hu, Xiong Cao, Yanqiu Feng   +15 more
wiley   +1 more source

Complete representation of action space and value in all dorsal striatal pathways

Cell Reports, 2021
Summary: The dorsal striatum plays a central role in the selection, execution, and evaluation of actions. An emerging model attributes action selection to the matrix and evaluation to the striosome compartment. Here, we use large-scale cell-type-specific
Moritz Weglage, Emil Wärnberg, Iakovos Lazaridis, Daniela Calvigioni, Ourania Tzortzi, Konstantinos Meletis   +5 more
doaj   +1 more source

Dissociating the Role of the Orbitofrontal Cortex and the Striatum in the Computation of Goal Values and Prediction Errors [PDF]

, 2008
To make sound economic decisions, the brain needs to compute several different value-related signals. These include goal values that measure the predicted reward that results from the outcome generated by each of the actions under consideration, decision
Camerer, Colin F., Hare, Todd A., O'Doherty, John P., Rangel, Antonio, Schultz, Wolfram   +4 more
core   +3 more sources

The role of the striatum in social behavior [PDF]

Frontiers in Neuroscience, 2013
Where and how does the brain code reward during social behavior? Almost all elements of the brain's reward circuit are modulated during social behavior. The striatum in particular is activated by rewards in social situations. However, its role in social behavior is still poorly understood.
Raymundo Býez-Mendoza, Wolfram Schultz
openaire   +4 more sources

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

Advanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song, Yifan Wang, Lili Wang, Chang Guo, Shiqi Liu, Yi Rong, Jiawen Tian, Chao Peng, Yuying Shao, Zhixiong Ma, Na Li, Jingliang Zhang, Zijun Peng, Xu Yan, Hangwei Fa, Xinyue Ma, Jie Dong, Jinping Ji, Chen Yang, Haocheng Chen, Jing Liang, Qi Sun, Yang Yang, Weining Ma, Zhuo Huang   +24 more
wiley   +1 more source

Why we interact : on the functional role of the striatum in the subjective experience of social interaction [PDF]

, 2014
Acknowledgments We thank Neil Macrae and Axel Cleeremans for comments on earlier versions of this manuscript. Furthermore, we are grateful to Dorothé Krug and Barbara Elghahwagi for their assistance in data acquisition.
Bente, Gary, Georgescu, Alexandra L, Kuzmanovic, Bojana, Pfeiffer, Ulrich J, Schilbach, Leonhard, Timmermans, Bert, Vogeley, Kai   +6 more
core   +1 more source

Targeting Neuronal Populations of the Striatum [PDF]

Frontiers in Neuroanatomy, 2011
The striatum is critically involved in motor and motivational functions. The dorsal striatum, caudate-putamen, is primarily implicated in motor control and the learning of habits and skills, whereas the ventral striatum, the nucleus accumbens, is essential for motivation and drug reinforcement.
Durieux, Pierre, Schiffmann, Serge N., de Kerchove d'Exaerde, Alban   +2 more
openaire   +5 more sources

The GLP1R Agonist Semaglutide Inhibits Reactive Astrocytes and Enhances the Efficacy of Neural Stem Cell Transplantation Therapy in Parkinson's Disease Mice

Advanced Science, EarlyView.
Compared to transplantation of neural stem cells (NSCs) alone, the combined treatment of NSCs with semaglutide more effectively improves motor dysfunction in Parkinson's disease (PD) mice. This synergistic effect may result from semaglutide's ability to suppress microglial activation, thereby preventing the transformation of resting astrocytes into ...
Dan Song, Xiaoya Zou, Di Ma, Yuying Zhao, Tingting Liu, Bibiao Shen, Oumei Cheng   +6 more
wiley   +1 more source

Obesity and Dietary Added Sugar Interact to Affect Postprandial GLP-1 and Its Relationship to Striatal Responses to Food Cues and Feeding Behavior

Frontiers in Endocrinology, 2021
It has been hypothesized that the incretin hormone, glucagon-like peptide-1 (GLP-1), decreases overeating by influencing mesolimbic brain regions that process food-cues, including the dorsal striatum. We previously showed that habitual added sugar intake
Sabrina Jones, Sabrina Jones, Shan Luo, Shan Luo, Shan Luo, Hilary M. Dorton, Hilary M. Dorton, Alexandra G. Yunker, Alexandra G. Yunker, Brendan Angelo, Brendan Angelo, Alexis Defendis, Alexis Defendis, John R. Monterosso, John R. Monterosso, Kathleen A. Page, Kathleen A. Page, Kathleen A. Page   +17 more
doaj   +1 more source