Results 61 to 70 of about 96,015 (345)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

T-duality to scattering amplitude and Wilson loop in non-commutative super Yang-Mills theory

Journal of High Energy Physics, 2018
We first perform bosonic T-duality transformation on one of the marginal TsT (T-duality, shift, T-duality)-deformed AdS 5×S 5 spacetime, which corresponds to 4D N=4 $$ \mathcal{N}=4 $$ non-commutative super Yang-Mills theory (NCSYM).
Song He, Hongfei Shu
doaj   +1 more source

Duality Symmetries of 4D Heterotic Strings

, 1993
Target space duality (T duality), which interchanges Kaluza--Klein and winding-mode excitations of the compactified heterotic string, is realized as a symmetry of a world-sheet action. Axion-dilaton duality (S duality), a conjectured nonperturbative SL(2,
Ashoke Sen, Azcarraga, Callan, Callan, Cecotti, Dirac, Dixon, Duff, Duff, Duff, Duff, Duff, Duff, Duff, Duff, Font, Gibbons, Goddard, Harvey, John H. Schwarz, Kallosh, Kugo, Maharana, Molera, Montonen, Narain, Narain, Nepomechie, Olive, Osborn, Rey, Schwinger, Schwinger, Sen, Sen, Shapere, Strominger, Teitelboim, Tseytlin, Tseytlin, Witten, Zwanziger, Zwanziger   +42 more
core   +2 more sources

A supermembrane description of string-string duality [PDF]

Physics Letters B, 1997
We show that the open membrane action on $T^3\times S^1/Z^2$ is equivalent to the closed membrane action on K3. The main difference between the two actions is that one generates the KK modes in the worldvolume action which is the strong coupling limit of \IIA\ while the other action generates the KK modes in a worldsheet action.
openaire   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Double field theory and geometric quantisation

Journal of High Energy Physics, 2021
We examine various properties of double field theory and the doubled string sigma model in the context of geometric quantisation. In particular we look at T-duality as the symplectic transformation related to an alternative choice of polarisation in the ...
Luigi Alfonsi, David S. Berman
doaj   +1 more source

String Theory Dynamics In Various Dimensions [PDF]

, 1995
The strong coupling dynamics of string theories in dimension $d\geq 4$ are studied. It is argued, among other things, that eleven-dimensional supergravity arises as a low energy limit of the ten-dimensional Type IIA superstring, and that a recently ...
Bars, Callan, Carr, Cremmer, Cremmer, Dabholkar, Dabholkar, Dai, Dine, Duff, Duff, Edward Witten, Gibbons, Ginsparg, Giveon, Hull, Huq, Julia, Kallosh, Nahm, Narain, Narain, Romans, Seiberg, Seiberg, Sen, Sen, Shenker, Strominger, Witten   +29 more
core   +3 more sources

String solitons and T-duality [PDF]

Journal of High Energy Physics, 2011
56 pages, 1 figure, 12 tables. v3: group theory analysis in former section 2 moved to section 7, refs.
Bergshoeff, Eric A., Riccioni, Fabio
openaire   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The T-dual symmetries of a bosonic string

European Physical Journal C: Particles and Fields, 2018
We investigate whether the symmetry transformations of a bosonic string are connected by T-duality. We start with a standard closed string theory. We continue with a modified open string theory, modified to preserve the symmetry transformations possessed
Ljubica Davidović, Branislav Sazdović
doaj   +1 more source