Results 41 to 50 of about 105,358 (314)
Journal of High Energy Physics, 2022 A supersymmetric Pati-Salam model with wrapping number equal to 5 has been constructed in Type IIA orientifolds on T 6 /(ℤ 2 × ℤ 2) with intersecting D6-branes recently.
Mudassar Sabir +3 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Uplift and towers of states in warped throat
Journal of High Energy Physics, 2023 We investigate the connection between the distance conjecture and the uplift potential. For this purpose, we consider the concrete model, the warped deformed conifold embedded into Type IIB flux compactifications, with the uplift potential produced by D ...
Min-Seok Seo
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Strings, matrix models, and meanders [PDF]
Nuclear Physics B - Proceedings Supplements, 1996 I briefly review the present status of bosonic strings and discretized random surfaces in D>1 which seem to be in a polymer rather than stringy phase. As an explicit example of what happens, I consider the Kazakov-Migdal model with a logarithmic potential which is exactly solvable for any D (at large D for an arbitrary potential). I discuss also the
openaire +2 more sources
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source
Journal of High Energy PhysicsFibre inflationary models are constructed in type-IIB string flux compactification. These models have been shown to be in agreement with the cosmological observations under appropriate choices of parameters, which originate from their string theory ...
Dibya Chakraborty, Rudnei O. Ramos
doaj +1 more source
Arthritis Care &Research, EarlyView.Objective This systematic review aimed to assess the diagnostic accuracy of algorithms used to identify rheumatoid arthritis and juvenile idiopathic arthritis in electronic health records. Methods We searched Medline, Embase, and Cochrane Central Register for Controlled Trials databases and included studies that validated case definitions against a ...
Constanza Saka‐Herrán +10 more
wiley +1 more source
Remark on modular weights in low-energy effective field theory from type II string theory
Journal of High Energy Physics, 2023 We revisit the modular weights in type IIB magnetized D-brane models. The simple analysis of wave function shows that the four-dimensional matter fields have the modular weight -1/2, but it may shift as one in type IIA intersecting D-brane models.
Shota Kikuchi +5 more
doaj +1 more source