Results 211 to 220 of about 5,540,038 (306)

Beyond Blood-Brain Barrier Crossing in Reperfusion-Era Ischemic Stroke: Interface-Matched Active-Entity Delivery and Translational Product Design. [PDF]

Int J Nanomedicine
Bu F, Cao Y, Chen F, Wen Y, Xiong L.
europepmc   +1 more source

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Spatial omics of neuroinflammation: insights across brain diseases. [PDF]

Front Immunol
Li M, Wang Q, Li J, Liu Y, Chen L, Liu P, Guo J.   +6 more
europepmc   +1 more source

Gut microbiota dysbiosis‐mediated gut NLRP3 inflammasome activation exacerbates corticospinal tract injury after intracerebral hemorrhage

Interdisciplinary Medicine, EarlyView.
Schematic depicting a gut‐brain pathway that exacerbates CST injury after ICH. Gut Microbiota Dysbiosis‐Mediated Gut NLRP3 Inflammasome Activation Exacerbates Corticospinal Tract Injury After Intracerebral Hemorrhage. Abstract Intracerebral hemorrhage (ICH) causes severe neurological deficits largely attributable to corticospinal tract (CST) injury ...
Meiqin Zeng, Meichang Peng, Chen He, Yanmeng Zhao, Zizhang Cheng, Mengchen Yu, Hao Tian, Lu Zhang, Wen Yuan, Qing Zeng, Jiandong Huang, Haitao Sun   +11 more
wiley   +1 more source

Hyperperfusion of stroke-like lesions and dilatation of the corresponding arteries are an epiphenomenon and not involved in their pathophysiology. [PDF]

Quant Imaging Med Surg
Finsterer J, Mehri S.
europepmc   +1 more source

Dignity's Dilemma: Categorical Objections to Autonomous Weapons and Their Pacifist Entailments

Journal of Applied Philosophy, EarlyView.
ABSTRACT Dignity objections to autonomous weapon systems are prominent in contemporary military ethics, yet their theoretical foundations remain underexamined. This article reconstructs those foundations, showing what categorical dignity objections require to function as absolute prohibitions.
Timothy Dubber
wiley   +1 more source

Advances in Multi-Omics Research on Post-Stroke Depression: From Molecular Mechanisms to Therapeutic Strategies. [PDF]

Neuropsychiatr Dis Treat
Feng G, Gao L, Zhao Y, Yu Z, Yang M, Chen Y, Xu X.   +6 more
europepmc   +1 more source

Understanding and interpreting composite outcomes in clinical research

Journal of Hospital Medicine, EarlyView.
Abstract Composite outcomes combine multiple endpoints into a single measure. They can capture overall treatment effects and increase statistical power, but have important interpretive challenges. Components of the outcome may vary in clinical importance, frequency, and treatment effect.
Mari Takashima, Brett Dyer, Amanda J. Ullman, Robert S. Ware   +3 more
wiley   +1 more source

Recurrent Large-Vessel Occlusion Associated With Flow Disturbance in a Carotid Web. [PDF]

J Clin Neurol
Jeon JH, Lee WJ, Sohn SI, Yun J.
europepmc   +1 more source