Results 241 to 250 of about 313,405 (294)

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

Myeloid‐Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis

Advanced Science, EarlyView.
Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.
Min Zhou, Yao Xiao, Ziyue Xu, Chengyu Yang, Jiang Li, Ya Liu, Ping Yin   +6 more
wiley   +1 more source

Effects of sitagliptin activation of the stromal cell-derived factor-1/CXC chemokine receptor 4 signaling pathway on the proliferation, apoptosis, inflammation, and osteogenic differentiation of human periodontal ligament stem cells induced by lipopolysaccharide. [PDF]

Hua Xi Kou Qiang Yi Xue Za Zhi
Tang X, Zhou Z, Li Q, Jiang D.
europepmc   +1 more source

Azab AK, Azab F, Blotta S, et al. RhoA and Rac1 GTPases play major and differential roles in stromal cell-derived factor-1-induced cell adhesion and chemotaxis in multiple myeloma. Blood. 2009;114(3):619-629.

Blood
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Solution Studies of Recombinant Human Stromal-Cell-Derived Factor-1

Protein Expression and Purification, 2001
Stromal-cell-derived factor-1 (SDF-1alpha) is an 8-kDa chemokine that is constitutively expressed in bone-marrow-derived stromal cells and has been identified as a ligand for the CXCR4 receptor. We produced the chemokine recombinantly as methionine-SDF-1alpha in Escherichia coli without the leader peptide sequence.
W D, Holmes, T G, Consler, W S, Dallas, W J, Rocque, D H, Willard   +4 more
openaire   +2 more sources

Cloning and characterization of chicken stromal cell derived factor-1

Developmental & Comparative Immunology, 2005
Stromal cell derived factor-1, SDF-1, belongs to the CXC family of chemokines and has been identified in mammals, amphibians, and fish. This chemokine has a diverse array of functions in organogenesis, hematopoeisis, B cell development and recruitment of immune system cells.
L R, Read, J A, Cumberbatch, M M, Buhr, A J, Bendall, S, Sharif   +4 more
openaire   +2 more sources

Platelets and Stromal Cell-Derived Factor-1 in Progenitor Cell Recruitment

Seminars in Thrombosis and Hemostasis, 2007
Stromal cell-derived factor-1 (SDF-1) is a CXC chemokine that binds to its sole counterreceptor, CXCR4. It is well reported that the SDF-1/CXCR4 signaling pathway is of vital importance to human development and to various pathophysiological phenomena, including hematopoiesis, angiogenesis, atherosclerosis, cancer growth, metastasis, and human ...
Konstantinos, Stellos, Meinrad, Gawaz
openaire   +2 more sources

Stromal Cell Derived Factor-1 (CXCL12) Chemokine Gene Variant in Myeloid Leukemias

Clinical Laboratory, 2014
Acute and chronic myeloid leukemia are initiated and sustained by a small, self-renewing population of leukemic stem cells, which produce progeny of a heterogeneous population of progenitor cells. CXCL12, a chemokine abundantly produced by the bone marrow microenvironment, and its receptor CXCR4 have crucial roles in malignant cell trafficking.
Hoda Mohamed A, El-Ghany, Zainab Ali, El-Saadany, Nevien Mohamed, Bahaa, Noha Yehia, Ibrahim, Salwa Mahmoud, Hussien   +4 more
openaire   +2 more sources

Exogenous stromal cell-derived factor-1 induces modest leukocyte recruitment in vivo

American Journal of Physiology-Heart and Circulatory Physiology, 2008
Stromal cell-derived factor-1 (SDF-1; CXCL12), a CXC chemokine, has been found to be involved in inflammation models in vivo and in cell adhesion, migration, and chemotaxis in vitro. This study aimed to determine whether exogenous SDF-1 induces leukocyte recruitment in mice.
Steven M, Kerfoot, Graciela, Andonegui, Claudine S, Bonder, Lixin, Liu   +3 more
openaire   +3 more sources