Stromal cell–derived factor 1 promotes angiogenesis via a heme oxygenase 1–dependent mechanism [PDF]
The Journal of Experimental Medicine, 2007 Stromal cell–derived factor 1 (SDF-1) plays a major role in the migration, recruitment, and retention of endothelial progenitor cells to sites of ischemic injury and contributes to neovascularization. We provide direct evidence demonstrating an important role for heme oxygenase 1 (HO-1) in mediating the proangiogenic effects of SDF-1.
Deshane, Jessy +14 more
openaire +5 more sources
Stromal cell-derived factor-1/CXC chemokine receptor 4 axis in injury repair and renal transplantation [PDF]
Journal of International Medical Research, 2019 Stem cell therapy has shown promise in treating a variety of pathologies, such as myocardial infarction, ischaemic stroke and organ transplantation. The stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor-4 (CXCR4) axis plays a key role in stem ...
Zejia Sun +5 more
doaj +2 more sources
Journal of Orthopaedic Surgery and Research, 2020 Objective To explore the possibility and mechanism of targeted blocking SDF-1/CXCR4 signaling pathway using three antagonists TN14003, T140, and AMD3100 in vivo, and to investigate the function of three antagonists in delay degeneration process of ...
Guoliang Wang +4 more
doaj +1 more source
Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia [PDF]
, 2006 Background— Stem and progenitor cell therapy is a novel approach to improve neovascularization and function of ischemic tissue. Enhanced tissue expression of chemoattractant factors such as stromal cell–derived factor 1 and vascular endothelial growth ...
Aicher, A +5 more
core +1 more source
SDF-1 and PDGF enhance [alpha]v[beta]5-mediated ERK activation and adhesion-independent growth of human pre-B cell lines [PDF]
, 2009 CD23 acts through the [alpha]v[beta]5 integrin to promote growth of human pre-B cell lines in an adhesion-independent manner. [alpha]v[beta]5 is expressed on normal B-cell precursors in the bone marrow.
Acharya, M. +3 more
core +2 more sources
Peptide and peptidomimetic ligands for CXC chemokine receptor 4 (CXCR4). [PDF]
, 2012 The development of novel peptide and peptidomimetic ligands for the CXC chemokine receptor 4 (CXCR4) as therapeutic agents for HIV-1 infection, cancer, and immune system diseases has grown over the last decade.
Fujii, Nobutaka, Oishi, Shinya
core +1 more source
Stromal Cell-Derived Factor-1 Promotes Cell Migration, Tumor Growth of Colorectal Metastasis
Neoplasia: An International Journal for Oncology Research, 2007 In a mouse model of established extrahepatic colorectal metastasis, we analyzed whether stromal cellderived factor (SDF) 1 stimulates tumor cell migration in vitro, angiogenesis, tumor growth in vivo.
Otto Kollmar +6 more
doaj +1 more source
Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer [PDF]
, 2017 Tumor epithelial cells (TEpCs) and spindle-shaped stromal cells, not associated with the vasculature, of patients with early breast cancer express osteoprotegerin (OPG), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), receptor activator ...
Borzone, Francisco Raúl +12 more
core +2 more sources
Stromal Cell-Derived Factor 1 Mediates Immune Cell Attraction upon Urinary Tract Infection
Cell Reports, 2017 Urinary tract infection (UTI) is the most common type of bacterial infection in humans. Fifty percent of all women will experience at least one UTI in their lifetime, with uropathogenic Escherichia coli (UPEC) accounting for 80% of reported cases.
Batya Isaacson +6 more
doaj +1 more source
Controlled Delivery of Sdf-1 Alpha and Igf-1: Cxcr4(+) Cell Recruitment and Functional Skeletal Muscle Recovery [PDF]
, 2015 Therapeutic delivery of regeneration-promoting biological factors directly to the site of injury has demonstrated its efficacy in various injury models.
Farrar, Roger P. +6 more
core +1 more source