Tumor Biology, 2017 C-X-C chemokine receptor type 4 and stromal cell–derived factor-1 were proven to play important roles in several types of cancer and in many biological processes connected with tumor growth, invasion, angiogenesis, and metastasis.
Yao-ping Li +6 more
doaj +1 more source
Mesenchymal stem cells with increased stromal cell-derived factor 1 expression enhanced fracture healing [PDF]
, 2014 Treatment of critical size bone defects pose a challenge in orthopedics. Stem cell therapy together with cytokines has the potential to improve bone repair as they cause the migration and homing of stem cells to the defect site. However, the engraftment,
Blunn, Gordon W. +5 more
core +2 more sources
Stromal Cell-Derived Factor-1 Retention and Cardioprotection for Ischemic Myocardium [PDF]
Circulation: Heart Failure, 2011 Background— Stromal cell-derived factor-1 (SDF-1) is a chemoattractant of stem/progenitor cells, and several studies have shown that SDF-1 may improve ventricular function after infarction. SDF-1 is cleaved by proteases including matrix metalloproteinase-2 (MMP-2) and CD26/dipeptidylpeptidase-4 (DPP-4), which are activated in ...
Sachiko, Kanki +7 more
openaire +2 more sources
Stromal cell-derived factor 1 regulates the actin organization of chondrocytes and chondrocyte hypertrophy. [PDF]
PLoS ONE, 2012 Stromal cell-derived factor 1 (SDF-1/CXCL12/PBSF) plays important roles in the biological and physiological functions of haematopoietic and mesenchymal stem cells.
Koichi Murata +12 more
doaj +1 more source
Platelet lysate as a serum substitute for 2D static and 3D perfusion culture of stromal vascular fraction cells from human adipose tissue [PDF]
, 2009 Fetal bovine serum (FBS) and fibroblast growth factor (FGF)-2 are key supplements for the culture of stromal vascular fraction (SVF) cells from adipose tissue, both for typical monolayer (2D) expansion and for streamlined generation of osteogenic ...
Alini, Mauro +8 more
core +1 more source
Stromal Derived Factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis
Molecular Cancer, 2006 Renal cell carcinoma (RCC) is characterized by organ-specific metastases. The chemokine stromal derived factor-1 (SDF-1/CXCL12) and its receptor CXCR4 have been suggested to regulate organ-specific metastasis in various other cancers.
Reckamp Karen +7 more
doaj +1 more source
Stromal Cell-Derived Factor-1 Stimulates Cell Recruitment, Vascularization and Osteogenic Differentiation [PDF]
Tissue Engineering Part A, 2013 The use of growth factors in osteogenic constructs to promote recruitment of bone forming endogenous cells is not clear, while the advantage of circumventing cell seeding techniques before implantation is highly recognized. Therefore, the additive effect of the chemokine stromal cell-derived factor-1α (SDF-1α) on endogenous cell recruitment and ...
Eman, Rhandy M +4 more
openaire +3 more sources
Hepatocyte growth factor, a key tumor-promoting factor in the tumor microenvironment [PDF]
, 2017 The tumor microenvironment plays a key role in tumor development and progression. Stromal cells secrete growth factors, cytokines and extracellular matrix proteins which promote growth, survival and metastatic spread of cancer cells.
Galemmo, Robert +3 more
core +2 more sources
SDF-1 and its receptor in the ventricles of rat with monocrotaline-induced pulmonary hypertension
European Pharmaceutical Journal, 2018 Aim: Chemokine stromal cell derived factor-1 (SDF-1) plays an important role in many processes such as apoptosis, proliferation, migration and angiogenesis, and these effects are mediated mostly by the receptor CXCR4.
Veteskova J. +7 more
doaj +1 more source
Inflammatory events drive neural stem cell migration by elevating stromal-derived factor 1 alpha
STEMedicine, 2020 Background: Ischemic stroke is the most common cause of ischemia-related death globally. Brain injuries due to stroke and trauma are typically followed by inflammation reactions within the central nervous system (CNS).
Ziyun Jiang, Mingliang Tang
doaj +1 more source