Results 51 to 60 of about 313,405 (295)

Imatinib treatment induces CD5+ B lymphocytes and IgM natural antibodies with anti-leukemic reactivity in patients with chronic myelogenous leukemia. [PDF]

PLoS ONE, 2011
Imatinib mesylate is a first line treatment of Chronic Myelogenous Leukemia and of a rare form of gastrointestinal stromal cancer, where the response to the drug is also linked to the immune system activation with production of antineoplastic cytokines ...
Silvia Catellani, Ivana Pierri, Marco Gobbi, Alessandro Poggi, Maria Raffaella Zocchi   +4 more
doaj   +1 more source

Culture of human cell lines by a pathogen-inactivated human platelet lysate [PDF]

, 2015
Alternatives to the use of fetal bovine serum (FBS) have been investigated to ensure xeno-free growth condition. In this study we evaluated the efficacy of human platelet lysate (PL) as a substitute of FBS for the in vitro culture of some human cell ...
Bonanno, G, Cicchetti, E, Fazzina, R, Fioravanti, D, Iudicone, P, Mariotti, A, Pierelli, Luca, Procoli, A, Scambia, G   +8 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Multifocal gastrointestinal stromal tumor with osseous metaplasia: a case report

Journal of Medical Case Reports, 2023
Background Gastrointestinal stromal tumor is considered the most common mesenchymal neoplasm of the gastrointestinal tract. The majority of gastrointestinal stromal tumor cases are located in the stomach and usually affects older adults.
Maryam Abdullah Al Saleem, Nida Mirzaman Khan, Tarek Mohammad ElSharkawy   +2 more
doaj   +1 more source

Platelet lysate-derived neuropeptide y influences migration and angiogenesis of human adipose tissue-derived stromal cells [PDF]

, 2018
Neuropeptide Y (NPY), a powerful neurotransmitter of the central nervous system, is a key regulator of angiogenesis and biology of adipose depots. Intriguingly, its peripheral vascular and angiogenic powerful activity is strictly associated to platelets,
Bordin, Antonella, Businaro, Rita, Capoano, Raffaele, Corsi, Mariangela, DE FALCO, Elena, Frati, Giacomo, Pagano, Francesca, Petrozza, Vincenzo, Pierangelatotta,, Procaccini, Eugenio, Salvati, Bruno, Scaccia, Eleonora, Siciliano, Camilla, Teresa Vietri, Maria   +13 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Zebrafish Caudal Haematopoietic Embryonic Stromal Tissue (CHEST) Cells Support Haematopoiesis. [PDF]

, 2017
Haematopoiesis is an essential process in early vertebrate development that occurs in different distinct spatial locations in the embryo that shift over time.
Aggio, Julian, Campbell, Clyde, Marquez, Gabriel, Stachura, David L, Traver, David, Wolf, Anja, Wright, Francis   +6 more
core   +1 more source

Stromal-cell-derived Factor 1-α Promotes Tumor Progression in Colorectal Cancer [PDF]

Journal of the Korean Society of Coloproctology, 2012
Although stromal-cell-derived factor (SDF)-1α is suggested to be involved in tumorigenicity and tumor angiogenesis, the clinicopathological significance of its expression in colorectal cancers is not fully understood. We examined SDF-1α expression in colorectal cancers and investigated its relationship to clinicopathological features such as tumor ...
Park, Se Jun, Ahn, Tae Sung, Cho, Sung Woo, Kim, Chang Jin, Jung, Dong Jun, Son, Myung Won, Bae, Sang Ho, Shin, Eung Jin, Lee, Moon Soo, Kim, Chang Ho, Baek, Moo Jun   +10 more
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Stromal Cell-Derived Factor-1 Antagonizes Slit/Robo SignalingIn Vivo [PDF]

The Journal of Neuroscience, 2007
Retinal ganglion cell axons exit the eye, enter the optic stalk, cross the ventral midline at the optic chiasm, and terminate in the optic tectum of the zebrafish. While in the optic stalk, they grow immediately adjacent to cells expressing the powerful retinal axon repellent slit2. The chemokine stromal cell-derived factor-1 (SDF1) is expressed within
Sreekanth H, Chalasani, Angela, Sabol, Hong, Xu, Michael A, Gyda, Kendall, Rasband, Michael, Granato, Chi-Bin, Chien, Jonathan A, Raper   +7 more
openaire   +2 more sources