Results 31 to 40 of about 337,689 (296)

Are mesenchymal stromal cells immune cells? [PDF]

Arthritis Research & Therapy, 2015
AbstractMesenchymal stromal cells (MSCs) are considered to be promising agents for the treatment of immunological disease. Although originally identified as precursor cells for mesenchymal lineages, in vitro studies have demonstrated that MSCs possess diverse immune regulatory capacities.
openaire   +3 more sources

Multipotent stromal cells skew monocytes towards an anti-inflammatory interleukin-10-producing phenotype by production of interleukin-6

Haematologica, 2013
Multipotent stromal cells have immunomodulatory capacities and have been used in transplantation and autoimmune diseases. One of the effects of multipotent stromal cells involves the inhibition of dendritic cell differentiation.
Sara M. Melief, Sacha B. Geutskens, Willem E. Fibbe, Helene Roelofs   +3 more
doaj   +1 more source

Emerging data supporting stromal cell therapeutic potential in cancer: reprogramming stromal cells of the tumor microenvironment for anti-cancer effects

Cancer Biology & Medicine, 2020
After more than a decade of controversy on the role of stromal cells in the tumor microenvironment, the emerging data shed light on pro-tumorigenic and potential anti-cancer factors, as well as on the roots of the discrepancies.
Armel H. Nwabo Kamdje, Paul F. Seke Etet, Richard Tagne Simo, Lorella Vecchio, Kiven Erique Lukong, Mauro Krampera   +5 more
doaj   +1 more source

Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFα-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction. [PDF]

PLoS ONE, 2015
Fibroblast-like stromal cells modulate cancer cells through secreted factors and adhesion, but those factors are not fully understood. Here, we have identified critical stromal factors that modulate cancer growth positively and negatively.
Manabu Kawada, Hiroyuki Inoue, Shun-ichi Ohba, Junjiro Yoshida, Tohru Masuda, Manabu Yamasaki, Ihomi Usami, Shuichi Sakamoto, Hikaru Abe, Takumi Watanabe, Takao Yamori, Masakatsu Shibasaki, Akio Nomoto   +12 more
doaj   +1 more source

Generation of mesenchymal stromal cells in the presence of platelet lysate: a phenotypic and functional comparison of umbilical cord blood- and bone marrow-derived progenitors

Haematologica, 2009
Background Mesenchymal stromal cells are employed in various different clinical settings in order to modulate immune response. However, relatively little is known about the mechanisms responsible for their immunomodulatory effects, which could be ...
Maria Antonietta Avanzini, Maria Ester Bernardo, Angela Maria Cometa, Cesare Perotti, Nadia Zaffaroni, Francesca Novara, Livia Visai, Antonia Moretta, Claudia Del Fante, Raffaella Villa, Lynne M. Ball, Willem E. Fibbe, Rita Maccario, Franco Locatelli   +13 more
doaj   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Canine Corneal Stromal Cells Have Multipotent Mesenchymal Stromal Cell Properties In Vitro [PDF]

Stem Cells and Development, 2020
The objective of this study was to determine whether corneal stromal cells (CSCs) from the limbal and central corneal stroma in dogs have multipotent mesenchymal stem/stromal cell (MSC) properties, and whether this cell population can be differentiated into keratocyte-like cells (KDCs). Normal, donated, mesocephalic dog corneas were used to isolate CSC
Julie T. Daniels, Christiane Kafarnik, Christiane Kafarnik, Marc Dziasko, Deborah J. Guest, Alyce McClellan   +5 more
openaire   +3 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Marginal reticular cells: a stromal subset directly descended from the lymphoid tissue organizer

Frontiers in Immunology, 2012
The architecture of secondary lymphoid organs (SLOs) is supported by several nonhematopoietic stromal cells. Currently it is established that two distinct stromal subsets, follicular dendritic cells and fibroblastic reticular cells, play crucial roles in
Tomoya eKatakai
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source