Results 21 to 30 of about 12,161,161 (260)
Stromal cell inhibition of anti-CD20 antibody mediated killing of B-cell malignancies
Frontiers in Cell and Developmental Biology, 2023 Introduction: The glycoengineered type II anti-CD20 monoclonal antibody obinutuzumab has been licensed for treatment in follicular non-Hodgkin lymphoma and B-CLL following clinical trials demonstrating superior outcomes to standard of care treatment ...
Ester Fagnano +10 more
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Mesenchymal stromal cells: clinical challenges and therapeutic opportunities
Cell Stem Cell, 2018 Summary Mesenchymal Stromal Cells (MSCs) have been the subject of clinical trials for more than a generation and the outcomes of advanced clinical trials have fallen short of expectations raised by encouraging pre-clinical animal data in a wide array of ...
J. Galipeau, L. Sensébé
semanticscholar +1 more source
Cancer Cell, 2020 To what extent stromal cells in the tumor microenvironment (TME) are transformed by colorectal cancer (CRC) cells is unexplored. To dissect alterations in these non-malignant cells, we performed single-cell multiomics sequencing of 21 patients with ...
Yuan Zhou +8 more
semanticscholar +1 more source
Mesenchymal stromal cells [PDF]
Current Opinion in Hematology, 2006 Our understanding of the biology and properties of mesenchymal stem cells or multipotent mesenchymal stromal cells has expanded dramatically over the last 3 years and is likely to have an impact on clinical practice in the near future, making a review of this topic both timely and relevantRecommendations regarding nomenclature and the definition of ...
openaire +2 more sources
Mesenchymal stromal cells and autoimmunity [PDF]
International Immunology, 2017 Abstract Mesenchymal stromal cells (MSCs) are committed progenitors of mesodermal origin that are found virtually in every organ and exhibit multilineage differentiation into osteocytes, adipocytes and chondrocytes. MSCs also mediate a wide spectrum of immunoregulatory activities that usually dampen innate and adaptive immune responses ...
Lizzia Raffaghello, Vito Pistoia
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Failure of intravenous or intracardiac delivery of mesenchymal stromal cells to improve outcomes after focal traumatic brain injury in the female rat. [PDF]
PLoS ONE, 2015 Mesenchymal stromal cells secrete a variety of anti-inflammatory factors and may provide a regenerative medicine option for the treatment of traumatic brain injury.
L Christine Turtzo +10 more
doaj +1 more source
Stromal cells of the mouse spleen [PDF]
Frontiers in Immunology, 2012 The composition and function of stromal cells in the white pulp of the spleen resemble to a large extent the situation in other secondary lymphoid organs such as lymph nodes. The stromal cells play an important role in the support and guidance of lymphocytes and myeloid cells in the T and B cell zones of the spleen.
den Haan, J.M.M. +2 more
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Haematologica, 2010 Background In vitro proliferative and differentiation potential of mesenchymal stromal cells generated from CD271+ bone marrow mononuclear cells (CD271-mesenchymal stromal cells) has been demonstrated in several earlier and recent reports. In the present
Selim Kuçi +16 more
doaj +1 more source
STAR Protocols, 2021 Summary: Bone marrow (BM) mesenchymal stromal cells play an important role in regulating stem cell quiescence and homeostasis; they are also key contributors to various hematological malignancies. However, human bone marrow stromal cells are difficult to
Hélène F.E. Gleitz +4 more
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Bovine endometrial stromal cells display osteogenic properties
Reproductive Biology and Endocrinology, 2008 The endometrium is central to mammalian fertility. The endometrial stromal cells are very dynamic, growing and differentiating throughout the estrous cycle and pregnancy.
Cavirani Sandro +4 more
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