Results 51 to 60 of about 12,161,161 (260)

A Substrate-Mimicking Basement Membrane Drives the Organization of Human Mesenchymal Stromal Cells and Endothelial Cells Into Perivascular Niche-Like Structures

Frontiers in Cell and Developmental Biology, 2021
Extracellular matrix-derived products (e.g. Matrigel) are widely used for in vitro cell cultures both as two-dimensional (2D) substrates and as three-dimensional (3D) encapsulation gels because of their ability to control cell phenotypes through ...
Valeria Perugini, Matteo Santin
doaj   +1 more source

Stromal Cells Maintain Immune Cell Homeostasis in Adipose Tissue via Production of Interleukin-33

Science immunology, 2019
Tissue-resident stromal cells control innate lymphoid cell–dependent immune homeostasis in adipose tissue. Stromal sources of IL-33 in fat depots White adipose tissue (WAT) is home to Tregs and group 2 innate lymphoid cells (ILC2s) that help keep ...
Tanel Mahlakõiv, A. Flamar, L. Johnston, Saya Moriyama, G. Putzel, P. Bryce, D. Artis   +6 more
semanticscholar   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Marginal reticular cells: a stromal subset directly descended from the lymphoid tissue organizer

Frontiers in Immunology, 2012
The architecture of secondary lymphoid organs (SLOs) is supported by several nonhematopoietic stromal cells. Currently it is established that two distinct stromal subsets, follicular dendritic cells and fibroblastic reticular cells, play crucial roles in
Tomoya eKatakai
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

A spiked human proteomic dataset from human osteogenic differentiated BMSCs and ASCs for use as a spectral library, for modelling pathways as well as protein mapping

Data in Brief, 2019
This article describes a mass spectrometry data set generated from osteogenic differentiated bone marrow stromal cells (BMSCs) and adipose tissue derived stromal cells (ASCs) of a 24-year old healthy donor.
Mehran Dadras, Katrin Marcus, Johannes Maximilian Wagner, Christoph Wallner, Mustafa Becerikli, Henriette Jaurich, Stephanie Dittfeld, Marcus Lehnhardt, Bettina Serschnitzki, Annika Guntermann, Lukas Schilde, Björn Behr, Caroline May   +12 more
doaj   +1 more source

Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity

Immunity, 2018
SUMMARY Stromal cells (SCs) establish the compartmentalization of lymphoid tissues critical to the immune response. However, the full diversity of lymph node (LN) SCs remains undefined.
Lauren B. Rodda, Erick Lu, Mariko L. Bennett, Caroline L. Sokol, Xiaoming Wang, S. Luther, B. Barres, A. Luster, Chun Jimmie Ye, J. Cyster   +9 more
semanticscholar   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells

Frontiers in Immunology, 2019
The epithelial layer creates a chemical and physical barrier at the forefront of intestinal mucosa, and immune cells beneath the surface epithelium are poised to react to extrinsic factors, to maintain tissue homeostasis.
Yosuke Kurashima, Yosuke Kurashima, Yosuke Kurashima, Yosuke Kurashima, Yosuke Kurashima, Daisuke Tokuhara, Daisuke Tokuhara, Mariko Kamioka, Mariko Kamioka, Mariko Kamioka, Mariko Kamioka, Yutaka Inagaki, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono   +16 more
doaj   +1 more source

Phagocytosis by stroma confounds coculture studies

iScience, 2021
Summary: Signals provided by the microenvironment can modify and circumvent pathway activities that are therapeutically targeted by drugs. Bone marrow stromal cell coculture models are frequently used to study the influence of the bone marrow niche on ex 
Sophie A. Herbst, Marta Stolarczyk, Tina Becirovic, Felix Czernilofsky, Yi Liu, Carolin Kolb, Mareike Knoll, Marco Herling, Carsten Müller-Tidow, Sascha Dietrich   +9 more
doaj   +1 more source