Results 51 to 60 of about 404,142 (315)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Generation of osteoinductive grafts by three-dimensional perfusion culture of human bone marrow cells into porous ceramic scaffolds [PDF]
, 2005 The main aims of this thesis were (i) to identify and develop a system that could be reproducibly used to streamline manufacture of osteoinductive grafts based on human bone marrow stromal cells (BMSC) in the context of regenerative medicine, (ii) to ...
Braccini, Alessandra
core +1 more source
Frontiers in Cell and Developmental Biology, 2021 Extracellular matrix-derived products (e.g. Matrigel) are widely used for in vitro cell cultures both as two-dimensional (2D) substrates and as three-dimensional (3D) encapsulation gels because of their ability to control cell phenotypes through ...
Valeria Perugini, Matteo Santin
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Marginal reticular cells: a stromal subset directly descended from the lymphoid tissue organizer
Frontiers in Immunology, 2012 The architecture of secondary lymphoid organs (SLOs) is supported by several nonhematopoietic stromal cells. Currently it is established that two distinct stromal subsets, follicular dendritic cells and fibroblastic reticular cells, play crucial roles in
Tomoya eKatakai
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Characterization of early mouse mesenchymal stem/progenitor cells for generating cartilage and study their role in endochondral ossification [PDF]
, 2016 Mesenchymal stem/ stromal cells (MSCs) isolated from mice have allowed to address some of the major issues that could not be investigated by using human MSCs.
Jaiswal, Sumit
core +1 more source
Reduced CCR2 Can Improve the Prognosis of Sarcoma by Remodeling the Tumor Microenvironment
International Journal of General Medicine, 2022 Baixing Wei, Hao Feng, Han Wu Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, People’s Republic of ChinaCorrespondence: Han Wu, Tel +86 043189876902, Email wu_han@jlu.edu.cnBackground: The tumor microenvironment (TME)
Wei B, Feng H, Wu H
doaj
Phagocytosis by stroma confounds coculture studies
iScience, 2021 Summary: Signals provided by the microenvironment can modify and circumvent pathway activities that are therapeutically targeted by drugs. Bone marrow stromal cell coculture models are frequently used to study the influence of the bone marrow niche on ex
Sophie A. Herbst +9 more
doaj +1 more source