Results 61 to 70 of about 12,161,161 (260)

Bone marrow stromal cells attenuate sepsis via prostaglandin E2—dependent reprogramming of host macrophages to increase their interleukin-10 production

Nature Medicine, 2008
Sepsis causes over 200,000 deaths yearly in the US; better treatments are urgently needed. Administering bone marrow stromal cells (BMSCs—also known as mesenchymal stem cells) to mice before or shortly after inducing sepsis by cecal ligation and puncture
K. Nemeth, Asada Leelahavanichkul, P. S. Yuen, Balázs Mayer, Alissa Parmelee, Kent Doi, P. Robey, Kantima Leelahavanichkul, B. Koller, Jared M Brown, Xuzhen Hu, Ivett Jelinek, R. Star, É. Mezey   +13 more
semanticscholar   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

There is no transfer of mitochondria from donor hematopoietic cells to recipient mesenchymal stromal cells after allogeneic hematopoietic stem cells transplantation in humans

Hematology, Transfusion and Cell Therapy
Introduction: Multipotent mesenchymal stromal cells are progenitors of the bone marrow stromal microenvironment that support hematopoiesis. Mitochondria, which can be transferred between cells via nanotubes or extracellular vesicles, play a key role in ...
Natalya Sats, Vadim Surin, Tatiana Abramova, Aleksandra Sadovskaya, Nataliya Petinati, Nikolay Kapranov, Ksenia Nikiforova, Nina Drize, Luisa Karaseva, Olga Pokrovskaya, Larisa Kuzmina, Elena Parovichnikova   +11 more
doaj   +1 more source

Reduced CCR2 Can Improve the Prognosis of Sarcoma by Remodeling the Tumor Microenvironment

International Journal of General Medicine, 2022
Baixing Wei, Hao Feng, Han Wu Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, People’s Republic of ChinaCorrespondence: Han Wu, Tel +86 043189876902, Email wu_han@jlu.edu.cnBackground: The tumor microenvironment (TME)
Wei B, Feng H, Wu H
doaj  

Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics (IFATS) and Science and the International Society for Cellular Therapy (ISCT)

Cytotherapy, 2013
Background aims Adipose tissue is a rich and very convenient source of cells for regenerative medicine therapeutic approaches. However, a characterization of the population of adipose-derived stromal and stem cells (ASCs) with the greatest therapeutic ...
P. Bourin, B. Bunnell, L. Casteilla, M. Dominici, A. Katz, K. March, H. Redl, J. P. Rubin, K. Yoshimura, J. Gimble   +9 more
semanticscholar   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Injury-driven stromal exhaustion disrupts intrinsic regenerative capability

Nature Communications
Bone marrow stromal cells, marked by leptin receptor (Lepr) and C-X-C motif chemokine ligand 12 (Cxcl12), orchestrate osteogenesis and maintain bone homeostasis.
Sixun Wu, Hirotaka Matsumoto, Keita Kondo, Aiko Kuroda, Jumpei Morita, Takeshi Moriishi, Shawn A. Hallett, Yuki Matsuo, Azumi Noguchi, Mitsuaki Ono, Makoto Abe, Kosei Ito, Shinsuke Ohba, Noriaki Ono, Yuki Matsushita   +14 more
doaj   +1 more source

Advances in stromal cell therapy for management of Alzheimer’s disease

Frontiers in Pharmacology, 2022
Deposition of misfolded proteins and synaptic failure affects the brain in Alzheimer’s disease (AD). Its progression results in amnesia and cognitive impairment.
Rashi Srivastava, Aidong Li, Tirtharaj Datta, Niraj Kumar Jha, Salehikram Talukder, Saurabh Kumar Jha, Saurabh Kumar Jha, Saurabh Kumar Jha, Zhe-Sheng Chen, Zhe-Sheng Chen   +9 more
doaj   +1 more source

Effect of Stromal Cells in Tumor Microenvironment on Metastasis Initiation

International Journal on Biological Sciences, 2018
The cellular environment where tumor cells reside is called the tumor microenvironment (TME), which consists of borders, blood vessels, lymph vessels, extracellular matrix (ECM), stromal cells, immune/inflammatory cells, secreted proteins, RNAs and small
Sen Guo, C. Deng
semanticscholar   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source