Results 41 to 50 of about 409,331 (346)

Targeting the tumor microenvironment in colorectal peritoneal metastases

, 2020
Peritoneal metastasis (PM) occurs in approximately one in four colorectal cancer (CRC) patients. The pathophysiology of colorectal PM remains poorly characterized. Also, the efficacy of current treatment modalities, including surgery and intraperitoneal (
Ceelen, Wim, De Wever, Olivier, Heriot, Alexander G., Narasimhan, Vignesh, Ramsay, Robert G.   +4 more
core   +1 more source

Differentiating small intestinal stromal tumors from primary small intestinal lymphomas using contrast-enhanced CT and texture analysis: a diagnostic study

Frontiers in Oncology
PurposeTo assess the diagnostic performance of morphological features combined with contrast-enhanced computed tomography (CECT) texture analysis in differentiating small intestinal stromal tumors (SISTs) from primary small intestinal lymphomas (PSILs ...
Zhihua Li, Yiying Wang, Da Xi, Jian Wang, Haiyang Lan, Xiaoning He, Na Zhao, Juan Xiao, Naiwen Mu, Jianlong Li, Lincheng Liu, Guanghui Yu, Guanghui Yu   +12 more
doaj   +1 more source

Gastrointestinal stromal tumor

Revista Cubana de Medicina Militar, 2021
Introduction: Gastrointestinal stromal tumor is the most frequent mesenchymal tumor in the digestive tract, causing bleeding and obstruction, with an incidence of 10 to 20 cases per million inhabitants.
Rene Santiago Borges Sandrino, Dioslan Moreno Ruiz, Enia Ramón Musibay, Wilfredo Ernesto Santiesteban Pupo   +3 more
doaj  

Blocking CD248 molecules in perivascular stromal cells of patients with systemic sclerosis strongly inhibits their differentiation toward myofibroblasts and proliferation: A new potential target for antifibrotic therapy [PDF]

, 2018
Background: Fibrosis may be considered the hallmark of systemic sclerosis (SSc), the end stage triggered by different pathological events. Transforming growth factor-β (TGF-β) and platelet-derived growth factor BB (PDGF-BB) are profibrotic molecules ...
Berardicurti O., Carubbi F., Ciccia F., Cipriani P., Di Bartolomeo S., Di Benedetto P., Giacomelli R., Guggino G., Liakouli V., Panzera N., Ruscitti P., Triolo G.   +11 more
core   +1 more source

Immunohistochemical expression of epithelial and stromal immunomodulatory signalling molecules is a prognostic indicator in breast cancer

BMC Research Notes, 2012
Background The immune system has paradoxical roles during cancer development and the prognostic significance of immune modulating factors is controversial.
Richardsen Elin, Uglehus Rebecca, Johnsen Stein, Busund Lill-Tove   +3 more
doaj   +1 more source

Gastrointestinal stromal tumor (GIST) of the Treitz’s angle– a very rare cause of high bowel obstruction [PDF]

, 2016
Gastrointestinal stromal tumors (GIST) are somewhat rare gastrointestinal tumors - approximately 1% to 3% incidence, but they are the most common mesenchymal neoplasms of the gastrointestinal tract.
Georgescu, Lota Corina, Pătraşcu, Traian, Tobă, Mădălina Elena, Ungureanu, Dan Florin   +3 more
core   +3 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Duodenal gastrointestinal stromal tumor resembling a pancreatic neuroendocrine tumor in a patient with neurofibromatosis type I (von Recklinghausen's disease): a case report

Journal of Medical Case Reports, 2010
Introduction Gastrointestinal stromal tumor is the most frequent nonepithelial tumor found in the gastrointestinal tract. One important clinical problem is that gastrointestinal stromal tumors, especially the extramural growth type, can be difficult to ...
Ohtake Shinji, Kobayashi Noritoshi, Kato Shingo, Kubota Kensuke, Endo Itaru, Inayama Yoshiaki, Nakajima Atsushi   +6 more
doaj   +1 more source

Role of Serine Proteases at the Tumor-Stroma Interface

Frontiers in Immunology, 2022
During tumor development, invasion and metastasis, the intimate interaction between tumor and stroma shapes the tumor microenvironment and dictates the fate of tumor cells.
Ravichandra Tagirasa, Euna Yoo
doaj   +1 more source

DDR2 controls breast tumor stiffness and metastasis by regulating integrin mediated mechanotransduction in CAFs [PDF]

, 2019
Biomechanical changes in the tumor microenvironment influence tumor progression and metastases. Collagen content and fiber organization within the tumor stroma are major contributors to biomechanical changes (e., tumor stiffness) and correlated with ...
Barcus, Craig E, Bayer, Samantha V.H., Brenot, Audrey, Ernst, Melanie, Grither, Whitney R, Hwang, Priscilla Y, Longmore, Gregory D, Pathak, Amit, Pence, Patrick, Walter, Christopher   +9 more
core   +1 more source