Results 51 to 60 of about 265,338 (259)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Robot‐assisted laparoscopic vesicule prostatectomy for mixed epithelial–stromal tumor of seminal vesicle

IJU Case Reports, 2020
Introduction Mixed epithelial–stromal tumor is a biphasic tumor with stromal and benign epithelial components. Only 40 cases of mixed epithelial‐stromal tumor originating from a seminal vesicle have previously been published in English. Case presentation
Yuki Masuo, Hisanori Taniguchi, Tomoaki Matsuzaki, Hidefumi Kinoshita, Chika Miyasaka, Chisato Ohe, Tadashi Matsuda   +6 more
doaj   +1 more source

Anagrelide for Gastrointestinal Stromal Tumor [PDF]

Clinical Cancer Research, 2019
Abstract Purpose: Gastrointestinal stromal tumor (GIST) is a common type of soft-tissue sarcoma. Imatinib, an inhibitor of KIT, platelet-derived growth factor receptor alpha (PDGFRA), and a few other tyrosine kinases, is highly effective for GIST, but advanced GISTs frequently progress on ...
Cervera Alejandra, Murumägi Astrid, Kulesskiy Evgeny, Sihto Harri, Joensuu Heikki, Mpindi John-Patrick, Icay Katherine, Wennerberg Krister, Varjosalo Markku, Kallioniemi Olli, Tynninen Olli, Pulkka Olli-Pekka, Laakkonen Pirjo, Lehtonen Rainer, Keskitalo Salla, Hautaniemi Sampsa, Cervera Alejandra, Murumägi Astrid, Kulesskiy Evgeny, Sihto Harri, Joensuu Heikki, Mpindi John-Patrick, Icay Katherine, Wennerberg Krister, Varjosalo Markku, Kallioniemi Olli, Tynninen Olli, Pulkka Olli-Pekka, Laakkonen Pirjo, Lehtonen Rainer, Keskitalo Salla, Hautaniemi Sampsa   +31 more
openaire   +3 more sources

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Gene expression down-regulation in CD90⁺ prostate tumor-associated stromal cells involves potential organ-specific genes

BMC Cancer, 2009
Background The prostate stroma is a key mediator of epithelial differentiation and development, and potentially plays a role in the initiation and progression of prostate cancer. The tumor-associated stroma is marked by increased expression of CD90/THY1.
Vêncio Ricardo ZN, Goo Young, Pascal Laura E, Page Laura S, Chambers Amber A, Liebeskind Emily S, Takayama Thomas K, True Lawrence D, Liu Alvin Y   +8 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Duodenal Stromal Tumor

Cerrahpaşa Medical Journal, 2014
Tumors of the duodenum are uncommon, and benign tumors are much rare. Overall 20-30% of gastrointestinal stromal tumors occur in the small bowel and about one third of these arise in the duodenum.
Sadık PEREK, Asiye PEREK, Kemal ŞARMAN, İlknur ERENLER KILIÇ, A. Ahad ANDİCAN   +4 more
doaj  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source