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Gastrointestinal Stromal Tumors [PDF]
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor of the gastrointestinal tract. Soon after GIST was recognized as a tumor driven by a KIT or platelet-derived growth factor receptor mutation, it became the first solid tumor target for tyrosine kinase inhibitor therapies.
Markku, Miettinen, Jerzy, Lasota
openaire +2 more sources
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the bowel. It most commonly arises in the stomach, followed by the small intestine, colorectum and the esophagus.
Usman Bashir +3 more
doaj +1 more source
SOD3 Expression in Tumor Stroma Provides the Tumor Vessel Maturity in Oral Squamous Cell Carcinoma
Tumor angiogenesis is one of the hallmarks of solid tumor development. The progressive tumor cells produce the angiogenic factors and promote tumor angiogenesis. However, how the tumor stromal cells influence tumor vascularization is still unclear.
May Wathone Oo +14 more
doaj +1 more source
Les tumeurs stromales gastro-intestinales (GIST) sont un groupe rare de tumeurs mésenchymateuses, localisé principalement dans le tractus gastro-intestinal.
Habib Bellamlih +8 more
doaj +1 more source
Background Neurofibromatosis type 1 is an inherited cancer predisposition syndrome that is caused by a mutation in the NF1 gene that encodes neurofibromin. Patients with neurofibromatosis type 1 have a higher risk of gastrointestinal stromal tumor.
B. G. Bharath +3 more
doaj +1 more source
Role of Serine Proteases at the Tumor-Stroma Interface
During tumor development, invasion and metastasis, the intimate interaction between tumor and stroma shapes the tumor microenvironment and dictates the fate of tumor cells.
Ravichandra Tagirasa, Euna Yoo
doaj +1 more source
PurposeTo assess the diagnostic performance of morphological features combined with contrast-enhanced computed tomography (CECT) texture analysis in differentiating small intestinal stromal tumors (SISTs) from primary small intestinal lymphomas (PSILs ...
Zhihua Li +12 more
doaj +1 more source
Gastrointestinal stromal tumor
Introduction: Gastrointestinal stromal tumor is the most frequent mesenchymal tumor in the digestive tract, causing bleeding and obstruction, with an incidence of 10 to 20 cases per million inhabitants.
Rene Santiago Borges Sandrino +3 more
doaj
Organoids in pediatric cancer research
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source

