Results 101 to 110 of about 6,791,323 (278)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Experimental Analysis of Hybrid Panels Combining Flax/PLA Composite with UHMWPE and Steel Under Ballistic Impact

Journal of Natural Fibers
This study investigates the feasibility of substituting UHMWPE and steel with flax/PLA green composite in ballistic applications with the objective to increase sustainability and cost-effectiveness.
Liu Jiao-Wang, Samuel Charca, Borja Valverde, J.A. Loya, Carlos Santiuste   +4 more
doaj   +1 more source

Combustion: Structural interaction in a viscoelastic material [PDF]

The effect of interaction between combustion processes and structural deformation of solid propellant was considered. The combustion analysis was performed on the basis of deformed crack geometry, which was determined from the structural analysis. On the
Chang, J. P., Chang, T. Y., Kumar, M., Kuo, K. K.   +3 more
core   +1 more source

An interactive graphics system to facilitate finite element structural analysis [PDF]

, 1973
The characteristics of an interactive graphics systems to facilitate the finite element method of structural analysis are described. The finite element model analysis consists of three phases: (1) preprocessing (model generation), (2) problem solution ...
Burk, R. C., Held, F. H.
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Glacios 2 Cryo-TEM and Smart EPU Software streamline Cryo-EM for drug design with higher throughput [PDF]

BIO Web of Conferences
Koh Adrian, Adams Michael, Yu Lingbo, Grollios Fanis, van Knippenberg Bart, Kotecha Abhay, Greber Basil, Raschdorf Oliver, Ortiz Julio, Pryor Edward, Lengyel Jeffrey   +10 more
doaj   +1 more source

Machine learning and data-driven methods for steel constitutive modeling: a state-of-the-art review and validation

Discover Civil Engineering
In this work we develop and validate neural-network (NN) constitutive models for structural steels under monotonic and cyclic loading, using internal-variable inputs to encode path dependence. For monotonic tension at $$200-800^{\circ }C$$ (Kirby-Preston
Stefanos Voulgaris, Spyros Chandrinos, Ilias Chamatidis, Giorgos Kazakis, Pantelis Tsakalis, Chara Ch. Mitropoulou, Stelios K. Georgantzinos, Denis Istrati, Nikos D. Lagaros   +8 more
doaj   +1 more source

Metamodel-based importance sampling for structural reliability analysis

, 2011
Structural reliability methods aim at computing the probability of failure of systems with respect to some prescribed performance functions. In modern engineering such functions usually resort to running an expensive-to-evaluate computational model (e.g.
Deheeger, F., Dubourg, V., Sudret, B.
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source