Results 71 to 80 of about 6,838,103 (298)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Fatigue and Structural Analysis of Azimuth Thruster Assembly [PDF]

, 2016
Composite is stated as constituent of two or more materials which retain their own physical and chemical property during the time of application, but produce a component which inherent the properties of its constituent materials and makes it better for ...
Ambadekar, P. (Prashant), Ayare, A. (Abhishek), Bade, S. (Sushmita), Desai-Patil, V. (Virendra), Mahajan, B. (Bhushan)   +4 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Aircraft Conceptual Structural Design Using the AMMIT Structural Analysis Tool [PDF]

Aircraft conceptual structural design is the process of developing and refining an idea for an aircraft into a feasible structural design. The process typically involves multiple evaluations of a single configuration and can require designers to examine ...
Horvath, Bryce L.
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Investigation of raw timber elements for the design of a hunting stand structure [PDF]

E3S Web of Conferences
There is an increasing need for less resource-intensive and waste-reducing measures in the design and production of timber structures. Traditionally, irregular branches from tree crowns are often left unused, despite making up nearly 50% of a tree's ...
Bergadewata Gerdan, Spahn Florian, Gata Kevin Moreno   +2 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Surrogate model for statics of fractional thin bar element and its equivalence with mass-spring metamaterial

Scientific Reports
The paper presents a two-level metametrial homogenization procedure, in which the mechanical behavior of a bar with non-uniform stiffness profile is considered. The connection between the microstructure (spring-mass model) and the surrogate model (simple
Krzysztof Szajek, Wojciech Sumelka
doaj   +1 more source

Brazilian Congress structural balance analysis

, 2016
In this work, we study the behavior of Brazilian politicians and political parties with the help of clustering algorithms for signed social networks. For this purpose, we extract and analyze a collection of signed networks representing voting sessions of
Frota, Yuri, Levorato, Mario
core   +2 more sources

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source