Results 71 to 80 of about 6,791,323 (278)

Fatigue and Structural Analysis of Azimuth Thruster Assembly [PDF]

, 2016
Composite is stated as constituent of two or more materials which retain their own physical and chemical property during the time of application, but produce a component which inherent the properties of its constituent materials and makes it better for ...
Ambadekar, P. (Prashant), Ayare, A. (Abhishek), Bade, S. (Sushmita), Desai-Patil, V. (Virendra), Mahajan, B. (Bhushan)   +4 more
core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Tuning the Magnetic Ordering Temperature of Hexagonal Ferrites by Structural Distortion Control [PDF]

, 2018
To tune the magnetic properties of hexagonal ferrites, a family of magnetoelectric multiferroic materials, by atomic-scale structural engineering, we studied the effect of structural distortion on the magnetic ordering temperature (TN).
Cao, Huibo, Cheng, Xuemei, Keavney, David J, Liu, Yaohua, Sinha, Kishan, Wang, Haohan, Wang, Wenbin, Wang, Xiao, Wu, Xifan, Xu, Xiaoshan, Yin, Yuewei, Zhou, Liying   +11 more
core   +4 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Aircraft Conceptual Structural Design Using the AMMIT Structural Analysis Tool [PDF]

Aircraft conceptual structural design is the process of developing and refining an idea for an aircraft into a feasible structural design. The process typically involves multiple evaluations of a single configuration and can require designers to examine ...
Horvath, Bryce L.
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Investigation of raw timber elements for the design of a hunting stand structure [PDF]

E3S Web of Conferences
There is an increasing need for less resource-intensive and waste-reducing measures in the design and production of timber structures. Traditionally, irregular branches from tree crowns are often left unused, despite making up nearly 50% of a tree's ...
Bergadewata Gerdan, Spahn Florian, Gata Kevin Moreno   +2 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Surrogate model for statics of fractional thin bar element and its equivalence with mass-spring metamaterial

Scientific Reports
The paper presents a two-level metametrial homogenization procedure, in which the mechanical behavior of a bar with non-uniform stiffness profile is considered. The connection between the microstructure (spring-mass model) and the surrogate model (simple
Krzysztof Szajek, Wojciech Sumelka
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source