Results 81 to 90 of about 6,838,103 (298)

Survey of Finite Element Method-Based Real-Time Simulations

Applied Sciences, 2019
The finite element method (FEM) has deservedly gained the reputation of the most powerful, highly efficient, and versatile numerical method in the field of structural analysis.
Dragan Marinkovic, Manfred Zehn
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Influence of Failure Strain of Different Aluminium Alloys on Dynamic Problems

Engineering Transactions, 2014
In this work an experimental-numerical methodology is devised for analyzing ductile fracture of two aluminum alloys under different values of stress triaxiality (0.2 ≤ η ≤ 1.2) and Lode parameter (−1 ≤ μ ≤ 0).
Marcos RODRIGUEZ-MILL´AN, Alvaro VAZ-ROMERO, Jose Antonio RODRIGUEZ-MARTINEZ, Alexis RUSINEK, Angel ARIAS   +4 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Computational design and evaluation of the mechanical and electrical behavior of a piezoelectric scaffold: a preclinical study

Frontiers in Bioengineering and Biotechnology
Piezoelectric scaffolds have been recently developed to explore their potential to enhance the bone regeneration process using the concept of piezoelectricity, which also inherently occurs in bone.
Vahid Badali, Vahid Badali, Sara Checa, Sara Checa, Manfred M. Zehn, Dragan Marinkovic, Melika Mohammadkhah   +6 more
doaj   +1 more source

CODSTRAN: Composite durability structural analysis [PDF]

CODSTRAN (COmposite Durability STRuctural ANalysis) is an integrated computer program being developed for the prediction of defect growth and fracture of composite structures subjected to service loads and environments. CODSTRAN is briefly described with
Chamis, C. C., Smith, G. T.
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Intelligent Structure Searching and Designs for Nanoclusters: Effective Units in Atomic Manufacturing

Advanced Intelligent Systems
Clusters, an aggregation of several to thousands of atoms, molecules, or ions, are the building blocks of novel functional materials by atomic manufacturing and exhibit excellent applications in catalysis, quantum information, and nanomedicine.
Junfeng Gao, Luneng Zhao, Yuan Chang, Yanxue Zhang, Shi Qiu, Yuanyuan Zhao, Hongsheng Liu, Jijun Zhao   +7 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source