Results 121 to 130 of about 425,057 (313)

Structural, morphological, mechanical and thermal properties of PMMA/SiC composites

open access: yesPolymers and Polymer Composites
In this study, silicon carbide (SiC) microfibers were added as reinforcement to improve the thermomechanical properties of poly (methyl methacrylate) polymer, PMMA, since this type of composite has not been explored well enough so far.
Vera Obradović   +4 more
doaj   +1 more source

Effect of Microstructure on Mechanical Properties of High Strength Steel Weld Metals

open access: yes, 2004
The effects of variations in alloying content on the microstructure and mechanical properties of high strength steel weld metals have been studied. Based on neural network modelling, weld metals were produced using shielded metal arc welding with nickel ...
Keehan, Enda
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Structural and Mechanical Properties of the Organic Matrix Layers of Nacre

open access: yes, 2003
The type of nanostructure referred to in biomineralization as a mineral bridge has been directly observed and measured in the organic matrix layers of nacre by transmission electron microscopy and scanning electron microscopy.
Soh AK   +3 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

An investigation into the strength properties of reclaimed timber joists

open access: yes
This research was designed to investigate the mechanical properties of timbers reclaimed from demolition, with the aim of generating a visual grade and model expression to grade these materials for structural reuse.
Smith, Michael J.
core  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Additive manufacturing of carbon nanocomposites for structural applications

open access: yesJournal of Materials Research and Technology
Additive manufacturing (AM), also known as 3D printing, has attracted a lot of attention in science and technology in recent years. Improvement in AM processes and materials are necessary, particularly for structural and load-bearing components in ...
Muhammed Hisham   +4 more
doaj   +1 more source

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