Results 1 to 10 of about 1,929,146 (335)

Unfreezing structural biology for drug discovery. [PDF]

Nat Chem Biol
Stachowski TR, Fischer M.
europepmc   +3 more sources

Structural biology

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1999
Protein crystallography has become a major technique for understanding cellular processes. This has come about through great advances in the technology of data collection and interpretation, particularly the use of synchrotron radiation. The ability to express eukaryotic genes in Escherichia coli is also important ...
Máire Convery, Caitrı́ona Dennis, Siân Rowsell, Gary J Pielak, Andreas Engel, J Bernard Heymann, Stephen Neidle, Alexis Wood, Rob Russell, Gianfranco Gilardi, Richard Newman, Sabine L Flitsch, Philip AS Lowden, Steve Matthews, Gerard J Kleywegt, Jon D Stewart   +15 more
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Structural biology: A golden era

PLOS Biology, 2023
In the past 2 decades, structural biology has transformed from a single technique used on single proteins to a multimodal integrative approach. Recently, protein structure prediction algorithms have opened new avenues to address challenging biological questions.
Carugo, Oliviero, Djinović-Carugo, Kristina   +1 more
openaire   +6 more sources

The Cryo-EM structures of two amphibian antimicrobial cross-β amyloid fibrils

Nature Communications, 2022
In this work the authors provide high-resolution structural support for the amyloid-antimicrobial link via functional amyloids displaying propeller-like and kinked cross-β fibrils.
Robert Bücker, Carolin Seuring, Cornelia Cazey, Katharina Veith, Maria García-Alai, Kay Grünewald, Meytal Landau   +6 more
doaj   +1 more source

Evolution of the SARS-CoV-2 spike protein in the human host

Nature Communications, 2022
The SARS-CoV-2 spike has been evolving in the human population. The variants of concern alpha and beta evolved to optimise spike openness and so ability to bind its receptor ACE2, the affinity towards the receptor, and stability upon receptor binding.
Antoni G. Wrobel, Donald J. Benton, Chloë Roustan, Annabel Borg, Saira Hussain, Stephen R. Martin, Peter B. Rosenthal, John J. Skehel, Steven J. Gamblin   +8 more
doaj   +1 more source

GRaNIE and GRaNPA: inference and evaluation of enhancer‐mediated gene regulatory networks

Molecular Systems Biology, 2023
Enhancers play a vital role in gene regulation and are critical in mediating the impact of noncoding genetic variants associated with complex traits. Enhancer activity is a cell‐type‐specific process regulated by transcription factors (TFs), epigenetic ...
Aryan Kamal, Christian Arnold, Annique Claringbould, Rim Moussa, Nila H Servaas, Maksim Kholmatov, Neha Daga, Daria Nogina, Sophia Mueller‐Dott, Armando Reyes‐Palomares, Giovanni Palla, Olga Sigalova, Daria Bunina, Caroline Pabst, Judith B Zaugg   +14 more
doaj   +1 more source

Characterization of Apicomplexan Amino Acid Transporters (ApiATs) in the Malaria Parasite Plasmodium falciparum

mSphere, 2021
During the symptomatic human blood phase, malaria parasites replicate within red blood cells. Parasite proliferation relies on the uptake of nutrients, such as amino acids, from the host cell and blood plasma, requiring transport across multiple ...
Jan Stephan Wichers, Carolina van Gelder, Gwendolin Fuchs, Julia Mareike Ruge, Emma Pietsch, Josie L. Ferreira, Soraya Safavi, Heidrun von Thien, Paul-Christian Burda, Paolo Mesén-Ramirez, Tobias Spielmann, Jan Strauss, Tim-Wolf Gilberger, Anna Bachmann   +13 more
doaj   +1 more source

Structure and function of the EA1 surface layer of Bacillus anthracis

Nature Communications, 2023
The Gram-positive spore-forming bacterium Bacillus anthracis is the causative agent of anthrax, a deadly disease mostly affecting wildlife and livestock, as well as representing a bioterrorism threat. Its cell surface is covered by the mutually exclusive
Adrià Sogues, Antonella Fioravanti, Wim Jonckheere, Els Pardon, Jan Steyaert, Han Remaut   +5 more
doaj   +1 more source

Structural features discriminating hybrid histidine kinase Rec domains from response regulator homologs

Nature Communications, 2023
Bacterial multi-step phospho-relays employ receiver domains that act as intermediaries in phosphoryl shuttling. Here, the authors show that such a domain does not experience structural changes upon pseudo-phosphorylation, in contrast to the well-studied ...
Mitchell Brüderlin, Raphael Böhm, Firas Fadel, Sebastian Hiller, Tilman Schirmer, Badri N. Dubey   +5 more
doaj   +1 more source

A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations

eLife, 2020
Synaptojanin1 (Synj1) is a phosphoinositide phosphatase, important in clathrin uncoating during endocytosis of presynaptic vesicles. It was identified as a potential drug target for Alzheimer’s disease, Down syndrome, and TBC1D24-associated epilepsy ...
Jone Paesmans, Ella Martin, Babette Deckers, Marjolijn Berghmans, Ritika Sethi, Yannick Loeys, Els Pardon, Jan Steyaert, Patrik Verstreken, Christian Galicia, Wim Versées   +10 more
doaj   +1 more source