Results 1 to 10 of about 1,910,238 (232)
The Cryo-EM structures of two amphibian antimicrobial cross-β amyloid fibrils
Nature Communications, 2022 In this work the authors provide high-resolution structural support for the amyloid-antimicrobial link via functional amyloids displaying propeller-like and kinked cross-β fibrils.
Robert Bücker +6 more
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Evolution of the SARS-CoV-2 spike protein in the human host
Nature Communications, 2022 The SARS-CoV-2 spike has been evolving in the human population. The variants of concern alpha and beta evolved to optimise spike openness and so ability to bind its receptor ACE2, the affinity towards the receptor, and stability upon receptor binding.
Antoni G. Wrobel +8 more
doaj +1 more source
GRaNIE and GRaNPA: inference and evaluation of enhancer‐mediated gene regulatory networks
Molecular Systems Biology, 2023 Enhancers play a vital role in gene regulation and are critical in mediating the impact of noncoding genetic variants associated with complex traits. Enhancer activity is a cell‐type‐specific process regulated by transcription factors (TFs), epigenetic ...
Aryan Kamal +14 more
doaj +1 more source
mSphere, 2021 During the symptomatic human blood phase, malaria parasites replicate within red blood cells. Parasite proliferation relies on the uptake of nutrients, such as amino acids, from the host cell and blood plasma, requiring transport across multiple ...
Jan Stephan Wichers +13 more
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Structure and function of the EA1 surface layer of Bacillus anthracis
Nature Communications, 2023 The Gram-positive spore-forming bacterium Bacillus anthracis is the causative agent of anthrax, a deadly disease mostly affecting wildlife and livestock, as well as representing a bioterrorism threat. Its cell surface is covered by the mutually exclusive
Adrià Sogues +5 more
doaj +1 more source
Nature Communications, 2023 Bacterial multi-step phospho-relays employ receiver domains that act as intermediaries in phosphoryl shuttling. Here, the authors show that such a domain does not experience structural changes upon pseudo-phosphorylation, in contrast to the well-studied ...
Mitchell Brüderlin +5 more
doaj +1 more source
eLife, 2020 Synaptojanin1 (Synj1) is a phosphoinositide phosphatase, important in clathrin uncoating during endocytosis of presynaptic vesicles. It was identified as a potential drug target for Alzheimer’s disease, Down syndrome, and TBC1D24-associated epilepsy ...
Jone Paesmans +10 more
doaj +1 more source
Adaptive laboratory evolution of microbial co‐cultures for improved metabolite secretion
Molecular Systems Biology, 2021 Adaptive laboratory evolution has proven highly effective for obtaining microorganisms with enhanced capabilities. Yet, this method is inherently restricted to the traits that are positively linked to cell fitness, such as nutrient utilization.
Dimitrios Konstantinidis +9 more
doaj +1 more source
The RCSB Protein Data Bank: views of structural biology for basic and applied research and education. [PDF]
, 2014 The RCSB Protein Data Bank (RCSB PDB, http://www.rcsb.org) provides access to 3D structures of biological macromolecules and is one of the leading resources in biology and biomedicine worldwide.
Berman, Helen M +14 more
core +4 more sources