Results 21 to 30 of about 1,910,238 (232)

Dual drug targeting to kill colon cancers

Cancer Medicine, 2022
Introduction Colorectal cancer (CRC) is driven by a small set of oncogenic and tumour suppressor mutations. However, different combinations of mutations often lead to poor tumour responses to individual anticancer drugs.
Silvia Paola Corona, Francesca Walker, Janet Weinstock, Guillaume Lessene, Maree Faux, Antony W. Burgess   +5 more
doaj   +1 more source

Algorithm engineering for optimal alignment of protein structure distance matrices [PDF]

, 2011
Protein structural alignment is an important problem in computational biology. In this paper, we present first successes on provably optimal pairwise alignment of protein inter-residue distance matrices, using the popular Dali scoring function.
A. Andreeva, A. Caprara, A. Marin, A. Schrijver, C. Berbalk, D. Wu, D.A. Pelta, E. Althaus, G. Mayr, Gunnar W. Klau, H. Hasegawa, H.P. Lenhof, I. Wohlers, Inken Wohlers, L. Holm, N. Malod-Dognin, P. Di Lena, R. Andonov, R. Kolodny, R.H. Lathrop, Rumen Andonov, T. Havel, T. Kawabata, W. Xie, W.R. Taylor   +24 more
core   +7 more sources

Capturing protein communities by structural proteomics in a thermophilic eukaryote

Molecular Systems Biology, 2017
The arrangement of proteins into complexes is a key organizational principle for many cellular functions. Although the topology of many complexes has been systematically analyzed in isolation, their molecular sociology in situ remains elusive.
Panagiotis L Kastritis, Francis J O'Reilly, Thomas Bock, Yuanyue Li, Matt Z Rogon, Katarzyna Buczak, Natalie Romanov, Matthew J Betts, Khanh Huy Bui, Wim J Hagen, Marco L Hennrich, Marie‐Therese Mackmull, Juri Rappsilber, Robert B Russell, Peer Bork, Martin Beck, Anne‐Claude Gavin   +16 more
doaj   +1 more source

Melatonin Reduces Oxidative Stress and Cardiovascular Changes Induced by Stanozolol in Rats Exposed to Swimming Exercise

Eurasian Journal of Medicine, 2019
Objective: Anabolic-androgenic steroids (AAS) are nominated for clinical use to promote protein synthesis in many therapeutic conditions. However, the indiscriminate use of AAS is related to hazardous cardiac disturbances and oxidative stress.
Gustavo Barbosa dos Santos, Marcelo José Machado Rodrigues, Estela Maria Gonçalves, Maria Cristina Cintra Gomes Marcondes, Miguel Arcanjo Areas   +4 more
doaj   +1 more source

Variable microtubule architecture in the malaria parasite

Nature Communications, 2023
Microtubules are a ubiquitous eukaryotic cytoskeletal element typically consisting of 13 protofilaments arranged in a hollow cylinder. Using CryoEM and subvolume averaging, Ferreira and Pražák et al.
Josie L. Ferreira, Vojtěch Pražák, Daven Vasishtan, Marc Siggel, Franziska Hentzschel, Annika M. Binder, Emma Pietsch, Jan Kosinski, Friedrich Frischknecht, Tim W. Gilberger, Kay Grünewald   +10 more
doaj   +1 more source

Graph Theory and Networks in Biology [PDF]

, 2006
In this paper, we present a survey of the use of graph theoretical techniques in Biology. In particular, we discuss recent work on identifying and modelling the structure of bio-molecular networks, as well as the application of centrality measures to ...
Mason, Oliver, Verwoerd, Mark
core   +3 more sources

An atlas of novel microtubule-associated proteins in the malaria parasite Plasmodium falciparum

mBio
Mature gametocytes of Plasmodium falciparum exhibit a characteristic falciform shape, which is conferred by a complex array of subpellicular microtubules (SPMTs) associated with the inner membrane complex (IMC).
Korbinian Niedermüller, Nick Piwon, Joëlle Paolo Mesen-Ramirez, Leah Zink, Sarah Lemcke, Benjamin Liffner, Cláudia F. Fernandes, Guilherme B. Farias, Arne Alder, Christian Löw, Noa Dahan, Danny W. Wilson, José Cubillán-Marín, Tim W. Gilberger   +13 more
doaj   +1 more source

Structure of the TFIIIC subcomplex τA provides insights into RNA polymerase III pre-initiation complex formation

Nature Communications, 2020
Transcription factor TFIIIC plays roles in Pol III transcription and in chromatin organization. CryoEM structure of the yeast TFIIIC subcomplex τA, a negative stain reconstruction of τA bound to the TFIIIB subunits Brf1 and TBP and accompanying ...
Matthias K. Vorländer, Anna Jungblut, Kai Karius, Florence Baudin, Helga Grötsch, Jan Kosinski, Christoph W. Müller   +6 more
doaj   +1 more source

Structural basis of BAK activation in mitochondrial apoptosis initiation

Nature Communications, 2022
The authors show that the mechanism of BAK activation in mitochondrial apoptosis involves cooperation between direct activation by BH3-only protein BID and BAK autoactivation, providing a unifying basis for BAK triggering by BH3 ligands.
Geetika Singh, Cristina D. Guibao, Jayaraman Seetharaman, Anup Aggarwal, Christy R. Grace, Dan E. McNamara, Sivaraja Vaithiyalingam, M. Brett Waddell, Tudor Moldoveanu   +8 more
doaj   +1 more source

10 simple rules to create a serious game, illustrated with examples from structural biology [PDF]

, 2018
Serious scientific games are games whose purpose is not only fun. In the field of science, the serious goals include crucial activities for scientists: outreach, teaching and research.
A Kawrykow, Antoine Taly, AO O’Hagan, AW Woolley, B M Good, D Centola, D Djaouti, D Kwak, D Michael, E Law, F Khatib, G McGill, GG Graham, H Jenkins, H Sauermann, HM Bik, I Iacovides, J Alvarez, J Belanich, J Franco, J Himmelstein, J Lee, J Lorenz, J Moult, JA Evans, JP Gee, JS Kim, Jérôme Waldispühl, KN Laland, L Mazzanti, M Gilski, Marc Baaden, N Ferey, N Férey, N Prestopnik, Nicolas Ferey, Olivier Delalande, R Das, R Das, R Follett, R McDaniel, RJ Ellis, S Cooper, S Cooper, S Doutreligne, S Horowitz, Samuela Pasquali, Scott Markel, SI O'Donoghue, V Curtis   +49 more
core   +7 more sources