Results 21 to 30 of about 1,929,146 (335)
Structural biology: a century-long journey into an unseen world [PDF]
, 2015 © Institute of Materials, Minerals and Mining 2015.When the first atomic structures of salt crystals were determined by the Braggs in 1912–1913, the analytical power of X-ray crystallography was immediately evident. Within a few decades the technique was
Curry, S
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Adaptations of Escherichia coli strains to oxidative stress are reflected in properties of their structural proteomes. [PDF]
, 2020 BACKGROUND:The reconstruction of metabolic networks and the three-dimensional coverage of protein structures have reached the genome-scale in the widely studied Escherichia coli K-12 MG1655 strain.
Catoiu, Edward +6 more
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Dual drug targeting to kill colon cancers
Cancer Medicine, 2022 Introduction Colorectal cancer (CRC) is driven by a small set of oncogenic and tumour suppressor mutations. However, different combinations of mutations often lead to poor tumour responses to individual anticancer drugs.
Silvia Paola Corona +5 more
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Structural analysis and architectural principles of the bacterial amyloid curli
Nature Communications, 2023 Two decades have passed since the initial proposition that amyloids are not only (toxic) byproducts of an unintended aggregation cascade, but that they can also be produced by an organism to serve a defined biological function.
Mike Sleutel +3 more
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Capturing protein communities by structural proteomics in a thermophilic eukaryote
Molecular Systems Biology, 2017 The arrangement of proteins into complexes is a key organizational principle for many cellular functions. Although the topology of many complexes has been systematically analyzed in isolation, their molecular sociology in situ remains elusive.
Panagiotis L Kastritis +16 more
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Algorithm engineering for optimal alignment of protein structure distance matrices [PDF]
, 2011 Protein structural alignment is an important problem in computational biology. In this paper, we present first successes on provably optimal pairwise alignment of protein inter-residue distance matrices, using the popular Dali scoring function.
A. Andreeva +24 more
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Variable microtubule architecture in the malaria parasite
Nature Communications, 2023 Microtubules are a ubiquitous eukaryotic cytoskeletal element typically consisting of 13 protofilaments arranged in a hollow cylinder. Using CryoEM and subvolume averaging, Ferreira and Pražák et al.
Josie L. Ferreira +10 more
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An atlas of novel microtubule-associated proteins in the malaria parasite Plasmodium falciparum
mBioMature gametocytes of Plasmodium falciparum exhibit a characteristic falciform shape, which is conferred by a complex array of subpellicular microtubules (SPMTs) associated with the inner membrane complex (IMC).
Korbinian Niedermüller +13 more
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Subspecies in the global human gut microbiome
Molecular Systems Biology, 2017 Population genomics of prokaryotes has been studied in depth in only a small number of primarily pathogenic bacteria, as genome sequences of isolates of diverse origin are lacking for most species.
Paul I Costea +9 more
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Nature Communications, 2020 Transcription factor TFIIIC plays roles in Pol III transcription and in chromatin organization. CryoEM structure of the yeast TFIIIC subcomplex τA, a negative stain reconstruction of τA bound to the TFIIIB subunits Brf1 and TBP and accompanying ...
Matthias K. Vorländer +6 more
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