Structural biology of large molecular complexes - what we learned from the master [PDF]
, 2021 Hao Wu
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Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
The review of recent advances in fish genetics and biotechnology [PDF]
, 2012 Great advances have been, and are being made in our knowledge of the genetics and molecular biology (including genomics, proteomics and structural biology).
Mgbabu , Christopher Nwokwa
core
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Impact of global structure on diffusive exploration of organelle networks [PDF]
, 2020 We investigate diffusive search on planar networks, motivated by tubular organelle networks in cell biology that contain molecules searching for reaction partners and binding sites.
Brown, Aidan I +2 more
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Deciphering a global network of functionally associated post‐translational modifications
Molecular Systems Biology, 2012 Various post‐translational modifications (PTMs) fine‐tune the functions of almost all eukaryotic proteins, and co‐regulation of different types of PTMs has been shown within and between a number of proteins.
Pablo Minguez +8 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]
, 2010 Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Keeble, Anthony H. +4 more
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Two-sample goodness-of-fit tests on the flat torus based on Wasserstein distance and their relevance to structural biology [PDF]
, 2023 Javier González-Delgado +3 more
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Genome-based structural biology
Progress in Biophysics and Molecular Biology, 1999 Spectacular achievements in whole genome sequencing open up new possibilities for structural research. Protein structures can now be studied in their natural genomic context. On the other hand, structure prediction algorithms can be improved using species-specific tendencies in folding patterns.
D, Frishman, H W, Mewes
openaire +2 more sources