Results 81 to 90 of about 10,579,206 (300)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Constructing Structural VAR Models with Conditional Independence Graphs [PDF]

In this paper graphical modelling is used to select a sparse structure for a multivariate time series model of New Zealand interest rates. In particular, we consider a recursive structural vector autoregressions that can subsequently be described ...
Granville Tunnicliffe Wilson, Les Oxley, Marco Reale   +2 more
core  

Modeling uncertainty, unawareness, and underspecification among Structural Causal Models [PDF]

We argue that linguistic communication of information about causal relations frequently involves epistemic states of not only uncertainty about, but also unawareness of causal facts.
Franke, Michael, Snider, Todd
core   +1 more source

Choice Function-Based Hyper-Heuristics for Causal Discovery under Linear Structural Equation Models

Biomimetics
Causal discovery is central to human cognition, and learning directed acyclic graphs (DAGs) is its foundation. Recently, many nature-inspired meta-heuristic optimization algorithms have been proposed to serve as the basis for DAG learning.
Yinglong Dang, Xiaoguang Gao, Zidong Wang   +2 more
doaj   +1 more source

Interdisciplinary Research on Healthy Aging: Introduction

Demographic Research, 2018
Background: This is an introduction to a Special Collection of Demographic Research on Interdisciplinary Research on Healthy Aging. The collection is an outcome of an international conference in China on biodemography and multistate modeling in healthy ...
Frans Willekens, James R. Carey, Qiang Li   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Causal misspecifications in econometric models [PDF]

We bridge together the graph-theoretic and the econometric approach for defining causality in statistical models to consider model misspecification problems.
Itkonen, Juha
core  

Higher Algebraic K-Theory of Causality

Entropy
Causal discovery involves searching intractably large spaces. Decomposing the search space into classes of observationally equivalent causal models is a well-studied avenue to making discovery tractable.
Sridhar Mahadevan
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source