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Graph-Based Search Procedure for Vector Autoregressive Models [PDF]
Vector Autoregressions (VARs) are a class of time series models commonly used in econometrics to study the dynamic effect of exogenous shocks to the economy.
Alessio Moneta, Peter Spirtes
core
Algorithmic recourse in sequential decision-making for long-term fairness
Frontiers in Big DataLong-term fairness in sequential decision-making is critical yet challenging, as decisions at each time step influence future opportunities and outcomes, potentially exacerbating existing disparities over time.
Francisco Gumucio, Lu Zhang
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Causal Depth: Aspects of a Scientific Realist Approach to Causal Explanation contra Humean Empiricism [PDF]
The purpose of this note is to clarify how the idea of "causal depth" can play a role in finding the more "approximately true" explanation through causal comparisons.
Khan, Haider
core
Comparing families of dynamic causal models [PDF]
, 2010 Mathematical models of scientific data can be formally compared using Bayesian model evidence. Previous applications in the biological sciences have mainly focussed on model selection in which one first selects the model with the highest evidence and ...
Stephan, Klaas E +46 more
core +2 more sources
BMC MedicineBackground Including structural determinants (e.g. criminalisation, stigma, inequitable gender norms) in dynamic HIV transmission models is important to help quantify their population-level impacts and guide implementation of effective interventions that
James Stannah +16 more
doaj +1 more source
IEEE AccessAutoimmune diseases pose a persistent challenge to clinical decision-making due to their heterogeneous presentations, episodic flare-ups, and complex pathophysiological mechanisms.
Harshit Sharma, Simran Kaur
doaj +1 more source
Wine quality analysis by the structural causal model (SCM)
Croatian Journal of Food Science and Technology, 2023 Bayes network modelling for structural causal analysis between wine physicochemical data and quantitative human quality blind assessments is applied. The large dataset of white and red "Vinho Verde'' wine samples from Portugal, which was available from ...
Želimir Kurtanjek
doaj
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source