Results 71 to 80 of about 158,058 (264)

From conceptualising to modelling structural determinants and interventions in HIV transmission dynamics models: a scoping review and methodological framework for evidence-based analyses

BMC Medicine
Background Including structural determinants (e.g. criminalisation, stigma, inequitable gender norms) in dynamic HIV transmission models is important to help quantify their population-level impacts and guide implementation of effective interventions that
James Stannah, Jorge Luis Flores Anato, Michael Pickles, Joseph Larmarange, Kate M. Mitchell, Adelina Artenie, Kostyantyn Dumchev, Serge Niangoran, Lucy Platt, Fern Terris-Prestholt, Aditya Singh, Jack Stone, Peter Vickerman, Andrew Phillips, Leigh Johnson, Mathieu Maheu-Giroux, Marie-Claude Boily   +16 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Mapping causal pathways with structural modes fingerprint for perovskite oxides

Machine Learning: Science and Technology
Causality is innate to the determination of the fundamental mechanism controlling any physical phenomena. However, combining causality within the standard practices of computational modelling to understand structure-functionality connections is extremely
Ayana Ghosh, Saurabh Ghosh
doaj   +1 more source

Higher Algebraic K-Theory of Causality

Entropy
Causal discovery involves searching intractably large spaces. Decomposing the search space into classes of observationally equivalent causal models is a well-studied avenue to making discovery tractable.
Sridhar Mahadevan
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Algorithmic recourse in sequential decision-making for long-term fairness

Frontiers in Big Data
Long-term fairness in sequential decision-making is critical yet challenging, as decisions at each time step influence future opportunities and outcomes, potentially exacerbating existing disparities over time.
Francisco Gumucio, Lu Zhang
doaj   +1 more source

Causal attribution in block-recursive social systems: A structural modeling perspective

Methodological Innovations, 2018
One method for causal analysis in the social sciences is structural modeling. Structural models, as used in this article, model the (causal) mechanism for a social phenomenon by recursively decomposing the multivariate distribution of the variables of ...
Guillaume Wunsch, Michel Mouchart, Federica Russo   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Causal Representation Learning for Predicting Autoimmune Disease Progression From Longitudinal Multimodal Clinical Data

IEEE Access
Autoimmune diseases pose a persistent challenge to clinical decision-making due to their heterogeneous presentations, episodic flare-ups, and complex pathophysiological mechanisms.
Harshit Sharma, Simran Kaur
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source