Results 91 to 100 of about 5,391,787 (331)
Untargeted metabolomics in doping control : detection of new markers of testosterone misuse by ultrahigh performance liquid chromatography coupled to high-resolution mass spectrometry [PDF]
, 2015 The use of untargeted metabolomics for the discovery of markers is a promising and virtually unexplored tool in the doping control field. Hybrid quadrupole time-of-flight (QTOF) and hybrid quadrupole Orbitrap (Q Exactive) mass spectrometers, coupled to ...
Deventer, Koen +18 more
core +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Biotecnología Vegetal, 2020 Melochia villosa (Mill.) Fawc. & Rendle is one of the species belonging to the Sterculiaceae family that has been little studied phytochemically. The objective of the research was to perform phytochemical analysis and characterization of the alcoholic ...
Fátima Rodríguez +4 more
doaj
Residual Dipolar Couplings in Structure Determination of Natural Products
Natural Products and Bioprospecting, 2018 The determination of natural products stereochemistry remains a formidable task. Residual dipolar couplings (RDCs) induced by anisotropic media are a powerful tool for determination of the stereochemistry of organic molecule in solution. This review will
Gao-Wei Li +4 more
doaj +1 more source
Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface.
Cell Reports, 2019 To evade immunity, many viruses express interferon antagonists that target STAT transcription factors as a major component of pathogenesis. Because of a lack of direct structural data, these interfaces are poorly understood.
Md. Alamgir Hossain +14 more
semanticscholar +1 more source
The isolation and structural elucidation of voacristine hydroxyindolenine [PDF]
Isolation and characterization of voacristine ...
Aksornvitaya, R. +4 more
core +1 more source
Total Synthesis and Structural Revision of the Alkaloid Incargranine B [PDF]
, 2013 Seeing double: Consideration of the biosynthetic origins of incargranineB, which was originally assigned an unprecedented indolo[1.7]naphthyridine structure, led to the proposal of a dipyrroloquinoline framework as a more biosynthetically feasible ...
Bates +8 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Frontiers in ChemistryBackground: Microbial secondary metabolites have shown promise as a source of novel antimicrobial agents. In this study, we aimed to isolate, characterize, and evaluate the antimicrobial activity of compound from a novel Streptomyces albofaciens strain ...
Neha Singh +10 more
doaj +1 more source
A Minor Dihydropyran Apocarotenoid from Mated Cultures of Blakeslea trispora
Molecules, 2012 The heterocyclic C15 apocarotenoid 1 was isolated from mated cultures of the strains F986 (+) and F921 (−) of Blakeslea trispora. This new compound formed during sexual interaction is a minor constituent of the culture media and its structure ...
Jesús F. Arteaga +4 more
doaj +1 more source