Results 91 to 100 of about 3,458,614 (298)
MoleculesNatural products such as polyketides are a fertile target for drug discovery. Methodologies relating to discovery, metabolism, synthesis and biosynthesis of polyketides have evolved considerably since they were first studied in the early 20th century ...
Candy Jiang, Paul J. Gates
doaj +1 more source
Metabolites, 2016 Although significant advances have been made in recent years, the structural elucidation of small molecules continues to remain a challenging issue for metabolite profiling.
Daniel A. Dias +7 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Understanding the first steps of the complement classical pathway: Structural studies on C1-antibody complexes [PDF]
, 2018 The complement system is a complex network of plasma and membrane-associated proteins, which can produce effective immune responses to infectious micro-organisms. Deficiencies of complement proteins cause diseases like systemic lupus erythematosus (SLE),
Sub Crystal and Structural Chemistry +2 more
core
Naturally occurring didemnaketals: Structural elucidation, features, and pharmacological activities
Bulletin of Faculty of Pharmacy Cairo University, 2015 Didemnaketals are rare terpenoid class reported only in the marine ascidian Didemnum species. They possess important biological activities like HIV-1 protease inhibitor, protein kinase inhibition, antimicrobial, antiproliferative, and cytotoxic.
Gamal A. Mohamed +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Structural Elucidation of Ciguatoxin Congeners by Fast-Atom Bombardment Tandem Mass Spectroscopy
, 2016 Structural Elucidation of Ciguatoxin Congeners by Fast-Atom Bombardment Tandem Mass ...
Hideo Naoki (2676340) +6 more
core +1 more source
Cytotoxic Terpenoids from the Roots of Dracocephalum taliense
Molecules, 2017 A chemical investigation of methanol extract from the roots of Dracocephalum taliense led to the isolation of a new aromatic abietane diterpenoid, 12-methoxy-18-hydroxy-sugiol (1), and one highly-oxygenated ursane triterpenoid, 2α,3α-dihydroxy-11α,12α ...
Yanyan Deng +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source