Results 51 to 60 of about 1,612,198 (310)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Enhancing the specific modulus of Al–Li alloys: A machine learning approach to micro-alloying element identification

Journal of Materials Research and Technology
To enhance the specific modulus of aerospace structural materials, this study employs machine learning methods to optimize the micro-alloying composition of Al–Li alloys. A total of 151 alloy composition-elastic modulus samples were analyzed.
Lyu Jing, Li Yanan, Li Xiwu, Zheng Lei, Xiao Wei, Liu Qilong, Liu Rui, Li Zhihui, Xiong Baiqing   +8 more
doaj   +1 more source

Effects of general structural stress on vibrational power flow

Journal of Low Frequency Noise, Vibration and Active Control, 2019
Vibrational power flow contains two types of information, namely, vibration velocity and structural internal force, and is an important parameter for measuring vibration level and transmission.
Hongdong Wang, Nian Yang, Xiaofeng Liang, Hong Yi   +3 more
doaj   +1 more source

Rock mass structural surface trace extraction based on transfer learning

Open Geosciences, 2022
To solve engineering geological problems, including water conservancy, transportation, and mining, it is necessary to obtain information on rock mass structures, such as slopes, foundation pits, and tunnels, in time.
Yi Xuefeng, Li Hao, Zhang Rongchun, Gongqiu Zhuoma, He Xiufeng, Liu Lanfa, Sun Yuxuan   +6 more
doaj   +1 more source

Affordances and Safe Design of Assistance Wearable Virtual Environment of Gesture [PDF]

, 2015
Safety and reliability are the main issues for designing assistance wearable virtual environment of technical gesture in aerospace, or health application domains.
Fass, Didier
core   +5 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Design revisions of complex building structures: work experience in Lithuania, legislative, organizational and technical aspects

Engineering Structures and Technologies, 2015
This paper presents an engineering survey based on experience of the authors during design and expertise of complex building structures in period of 2000–2014.
Michail Samofalov, Vytautas Papinigis
doaj   +1 more source

Performance-based earthquake engineering methodology for seismic analysis of nuclear cable tray system

Nuclear Engineering and Technology, 2021
The Pacific Earthquake Engineering Research (PEER) Center has been developing a performance-based earthquake engineering (PBEE) methodology, which is based on explicit determination of performance, e.g., monetary losses, in a probabilistic manner where ...
Baofeng Huang
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Applications of generative design in structural engineering [PDF]

Revista ingeniería de construcción, 2021
G. Díaz, R. F. Herrera, F. C. Muñoz-La Rivera, E. Atencio   +3 more
openaire   +1 more source