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Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi+3 more
wiley +1 more source
Designing by Geometry. Rankine's Theorems of Transformation of Structures. [PDF]
William John Macquorn Rankine (1820-1872) was one of the main figures in establishing engineering science in the second half of the 19th. Century. His Manual of Applied Mechanics (1858) gathers most of his contributions to strength of materials and ...
Huerta Fernández, Santiago
core +1 more source
Transfer of Individual Micro- and Nanoparticles for High- Precision 3D Analysis Using 360° Electron Tomography [PDF]
A versatile approach is demonstrated, providing a general routine for an extensive and advanced 3D characterization of individually selected micro- and nanoparticles, enabling the combination of complementary and scale-bridging techniques ...
Aert+55 more
core +1 more source
Self-cyclisation as a general and efficient platform for peptide and protein macrocyclisation
Head-to-tail macrocyclization of proteins and peptides can increase their structural stability, however, potential polymerization can lead to reduced yields.
Xinying Jia+10 more
semanticscholar +1 more source
The power of microRNA regulation—insights into immunity and metabolism
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto+2 more
wiley +1 more source
A Finite Element‑Based Methodology for the Thermo‑mechanical Analysis of Early Age Behavior in Concrete Structures [PDF]
This paper presents a general procedure based on fracture mechanics models in order to analyze the level of cracking and structural safety in reinforced concrete elements at early ages, depending on the stripping time.
Cabezas, Joaquín+4 more
core +3 more sources
ON THE THREAT OF SUPPLIERS FOR THE ENGINEERING CONSULTING AND DESIGN SERVICES FIRMS [PDF]
In the case of companies from engineering consulting and design services industry the classic models of analysis (e.g. Porter's five forces for structural analysis) exhibit interesting aspects in comparison with the situation when applied to traditional ...
Gabriel Sorin STROE
doaj
This paper presents an engineering survey based on experience of the authors during design and expertise of complex building structures in period of 2000–2014.
Michail Samofalov, Vytautas Papinigis
doaj +1 more source
A stepwise emergence of evolution in the RNA world
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
The structural engineering community often deals with the issue of inelastic incursions of the structural response. Although buildings situated in seismic regions are usually designed using elastic analysis, most encounter significant inelastic ...
Ruben Iacob Munteanu+3 more
doaj +1 more source