Results 71 to 80 of about 20,133 (313)

Application of finite element analysis in the formal analysis of ancient architectural plaque section

open access: yesNonlinear Engineering
Ancient architecture in Tibet has attracted considerable research attention because of its historical, religious, and artistic significance. Because the design and construction of ancient buildings often do not have the same detailed documentation as ...
Su Wen, Hua Yixiong
doaj   +1 more source

CFD Simulation of the Interference Effects of Wind Pressures in Building Groups

open access: yesMATEC Web of Conferences, 2018
The effect of interference is a hot topic in structural wind engineering. In order to investigate the phenomena of this effect, some cases, including single interfered building, double interfered buildings and building matrixes, were simulated by the ...
Sun Yi, Wang Mei, Liu Bowei
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Structural and technological solutions for engineering and geological surveys, design and operation of buildings and structures on clay soils [PDF]

open access: yesBIO Web of Conferences
The paper offers design and technological solutions and recommendations for engineering and geological surveys, as well as the design and operation of buildings and structures on clay soils in Stavropol.
Ovchinnikova Svetlana   +5 more
doaj   +1 more source

Finding the strain –stress state of engineering buildings. Optimization of structural solutions

open access: yesScience and Transport Progress, 2011
Industrial pipes are an integral part of the complex structures of enterprises of metallurgical, chemical and other industries from the moment of their advent. Their purpose is to exhaust industrial wastes with residual content of hazardous substances on a considerable height.
Volkova, V. Ye., Oleynik, M. S.
openaire   +3 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

Structural Vibration Comfort: A Review of Recent Developments

open access: yesBuildings
With continuous improvements in the social economy and living standards of individuals, the vibration comfort of building structures has gradually been emphasized by academic and engineering communities, such as vehicle-induced vibrations in buildings ...
Weiping Xie, Yumeng Hua
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

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