Results 71 to 80 of about 17,152,857 (276)

Structural damage identification using millimeter wave imaging and image processing

open access: yes, 2017
In the past decades, structural health monitoring (SHM) has received wide attention in preventing the sudden failure of structural components by identifying the damages in its early stages.
Samali, Bijan (R17646)   +2 more
core  

Estimation of the Size of a Growing Crack Through Strain Sensing Under Uncertainty

open access: yesEngineering Proceedings
Fatigue cracks in highly stressed regions of marine structures, caused primarily due to wave loading, are critical life-limiting factors that can lead to structural failure. Structural Health Monitoring (SHM) systems offer the ability to remotely monitor
Anastasia Valma   +2 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

Sub-pixel edge detection for structural health monitoring

open access: yes, 2009
In structural engineering it is essential to monitor the health of structural members under various load conditions. Traditionally, engineers are required to travel on site to retrieve various test results.
Uy, Brian (R9735)   +3 more
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

On the Reliability of a Solitary Wave Based Transducer to Determine the Characteristics of Some Materials

open access: yesSensors, 2015
In the study presented in this article we investigated the feasibility and the reliability of a transducer design for the nondestructive evaluation (NDE) of the stiffness of structural materials.
Wen Deng   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Case study : structural health monitoring of timber bridges using dynamic frequency analysis (DFA)

open access: yes, 2017
Australia has numerous ageing timber bridges in service. The structural efficiency of the majority of them have been impaired over time and their capacity is not known. There is, therefore, a critical need to develop new methods that will enable the load
Rashidi, Maria (R18339)   +4 more
core  

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