Results 71 to 80 of about 1,183,105 (286)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

On the Reliability of a Solitary Wave Based Transducer to Determine the Characteristics of Some Materials

Sensors, 2015
In the study presented in this article we investigated the feasibility and the reliability of a transducer design for the nondestructive evaluation (NDE) of the stiffness of structural materials.
Wen Deng, Amir Nasrollahi, Piervincenzo Rizzo, Kaiyuan Li   +3 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Impact Monitoring for Aircraft Smart Composite Skins Based on a Lightweight Sensor Network and Characteristic Digital Sequences

Sensors, 2018
Due to the growing use of composite materials in aircraft structures, Aircraft Smart Composite Skins (ASCSs) which have the capability of impact monitoring for large-scale composite structures need to be developed.
Lei Qiu, Xiaolei Deng, Shenfang Yuan, YongAn Huang, Yuanqiang Ren   +4 more
doaj   +1 more source

SMARTFIBER: enabling cost-effective, miniaturized structural health-monitoring of composite structures [PDF]

, 2011
C
Degrieck, Joris, Lammens, Nicolas, Luyckx, Geert   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Experimental Study on Stress Wave Propagation Crossing the Jointed Specimen with Different JRCs

Shock and Vibration, 2021
Most of the rock masses in the outer crust of the Earth are discontinuous. They are divided by joints, faults, fractures, etc. And those discontinuities, generally referred to as joints, greatly affect the property of the rock masses.
S.N. Hong, H.B. Li, L.F. Rong
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Vibration-based structural health monitoring [PDF]

, 2015
University of Technology Sydney. Faculty of Engineering and Information Technology.Ageing and degradation of the infrastructures, especially critical infrastructures (such as power plants, high-rise buildings, long-span bridges, dams, airports, railway ...
Makki Alamdari, M
core  

Structural Health Monitoring by Recursive Bayesian Filtering [PDF]

, 2009
A new vision of structural health monitoring (SHM) is presented, in which the ultimate goal of SHM is not limited to damage identification, but to describe the structure by a probabilistic model, whose parameters and uncertainty are periodically updated ...
Chen, Yangbo, Feng, Maria Q.
core   +2 more sources