Results 91 to 100 of about 1,187,415 (342)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2020 Structural health monitoring systems are employed to evaluate the state of structures to detect damage, bringing economical and safety benefits. The electromechanical impedance technique is a promising damage detection tool since it evaluates structural ...
Vieira Filho, Jozue [UNESP] +3 more
core +1 more source
Sensors, 2018 Due to the growing use of composite materials in aircraft structures, Aircraft Smart Composite Skins (ASCSs) which have the capability of impact monitoring for large-scale composite structures need to be developed.
Lei Qiu +4 more
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Structural Health Monitoring (SHM) using torsional guided wave EMATs [PDF]
, 2016 Torsional guided wave inspection is widely used for pipeline inspection. Most commonly piezoelectric and magnetostrictive transducers are used to generate torsional guided waves.
Balint Herdovics +3 more
core +1 more source
Experimental Study on Stress Wave Propagation Crossing the Jointed Specimen with Different JRCs
Shock and Vibration, 2021 Most of the rock masses in the outer crust of the Earth are discontinuous. They are divided by joints, faults, fractures, etc. And those discontinuities, generally referred to as joints, greatly affect the property of the rock masses.
S.N. Hong, H.B. Li, L.F. Rong
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Structural damage identification using millimeter wave imaging and image processing
, 2017 In the past decades, structural health monitoring (SHM) has received wide attention in preventing the sudden failure of structural components by identifying the damages in its early stages.
Samali, Bijan (R17646) +2 more
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source