Results 81 to 90 of about 1,187,415 (342)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
TECHNIQUES FOR SPECIAL FOLLOWING OF THE DEGRADATIONS DEVELOPMENT FOR A RAILWAY PASSAGE
Journal of Engineering Science (Chişinău), 2023 Nowadays, most of the transportation infrastructure is already built, the main challenge being the maintenance of these structures in optimal conditions of safety and comfort for users.
BOACĂ, Gheorghiță +3 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Structural Health Monitoring [PDF]
, 2006 Foreword. Chapter 1. Introduction to SHM (Daniel L. Balageas). Chapter 2. Vibration-based techniques for SHM (Claus-Peter Fritzen). Chapter 3. Fiber-optics sensors (Alfredo Guemes and Jose M. Menendez). Chapter 4. SHM with piezoelectric sensors (Philippe Guy and Thomas Monnier). Chapter 5.
openaire +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
On the standardization of procedures for Structural Health Monitoring [PDF]
, 2019 The aim of this paper is to outline the different aspects of the Structural Health Monitoring process that should be standardized in order to provide the stakeholders with consensual procedures for their implementation and use on the lifecycle, thereby ...
Limongelli M. P.
core
Sensors, 2015 In the study presented in this article we investigated the feasibility and the reliability of a transducer design for the nondestructive evaluation (NDE) of the stiffness of structural materials.
Wen Deng +3 more
doaj +1 more source