Results 21 to 30 of about 1,015,002 (311)

Dramatic Differences between the Structural Susceptibility of the S1 Pre- and S2 Postfusion States of the SARS-CoV-2 Spike Protein to External Electric Fields Revealed by Molecular Dynamics Simulations

Viruses, 2023
In its prefusion state, the SARS-CoV-2 spike protein (similarly to other class I viral fusion proteins) is metastable, which is considered to be an important feature for optimizing or regulating its functions. After the binding process of its S1 subunit (
Alexander Lipskij, Claudia Arbeitman, Pablo Rojas, Pedro Ojeda-May, Martin E. Garcia   +4 more
doaj   +1 more source

Modal P-delta – simplified geometric nonlinear method by using modal and buckling analysis

Revista IBRACON de Estruturas e Materiais, 2022
Recent works show that in structures, there is a relationship between the natural period of vibration and global second-order effects. This relationship occurs because both depend on the stiffness matrix and the mass matrix of the structure. In this work,
Wagner Almeida Ferreira, Jeffer Roussell Cordova De La Cruz, Iván Darío Gómez Araujo, Jesús Antonio Garcia Sánchez   +3 more
doaj   +1 more source

Soil degradation and recovery – changes in organic matter fractions and structural stability [PDF]

, 2020
The combination of concurrent soil degradation and restoration scenarios in a long-term experiment with contrasting treatments under steady-state conditions, similar soil texture and climate make the Highfield land-use change experiment at Rothamsted ...
Schjonning, P., Watts, C. W., Christensen, B. T, Munkholm, L. J., Obour, P. B., Jensen, J. L.   +5 more
core   +1 more source

Stability analysis of pit slopes in Zapadno-Ozerny quarry to ensure mine safety [PDF]

E3S Web of Conferences
The article discusses the design parameters of open pit slopes and the approach to calculating the stability of open pit slopes. The main deformations of slopes of open pits are considered.
Pykhteeva N.F., Andreeva O.N., Koltsov P.V.   +2 more
doaj   +1 more source

Thioflavin T fluoresces as excimer in highly concentrated aqueous solutions and as monomer being incorporated in amyloid fibrils

Scientific Reports, 2017
Fluorescence of thioflavin T (ThT) is a proven tool for amyloid fibrils study. The correct model of ThT binding to fibrils is crucial to clarify amyloid fibrils structure and mechanism of their formation.
Anna I. Sulatskaya, Andrey V. Lavysh, Alexander A. Maskevich, Irina M. Kuznetsova, Konstantin K. Turoverov   +4 more
doaj   +1 more source

Beyond the Excluded Volume Effects: Mechanistic Complexity of the Crowded Milieu

Molecules, 2015
Macromolecular crowding is known to affect protein folding, binding of small molecules, interaction with nucleic acids, enzymatic activity, protein-protein interactions, and protein aggregation.
Irina M. Kuznetsova, Boris Y. Zaslavsky, Leonid Breydo, Konstantin K. Turoverov, Vladimir N. Uversky   +4 more
doaj   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

Looking at the recent advances in understanding α-synuclein and its aggregation through the proteoform prism [version 1; referees: 2 approved]

F1000Research, 2017
Despite attracting the close attention of multiple researchers for the past 25 years, α-synuclein continues to be an enigma, hiding sacred truth related to its structure, function, and dysfunction, concealing mechanisms of its pathological spread within ...
Vladimir N. Uversky
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Stress-Induced Evolution of the Nucleolus: The Role of Ribosomal Intergenic Spacer (rIGS) Transcripts

Biomolecules
It became clear more than 20 years ago that the nucleolus not only performs the most important biological function of assembling ribonucleic particles but is also a key controller of many cellular processes, participating in cellular adaptation to stress.
Anastasia A. Gavrilova, Margarita V. Neklesova, Yuliya A. Zagryadskaya, Irina M. Kuznetsova, Konstantin K. Turoverov, Alexander V. Fonin   +5 more
doaj   +1 more source