Reorganization of Cell Compartmentalization Induced by Stress
Biomolecules, 2022 The discovery of intrinsically disordered proteins (IDPs) that do not have an ordered structure and nevertheless perform essential functions has opened a new era in the understanding of cellular compartmentalization.
Anna S. Fefilova +5 more
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Structure and stability of recombinant bovine odorant-binding protein: I. Design and analysis of monomeric mutants [PDF]
PeerJ, 2016 Bovine odorant-binding protein (bOBP) differs from other lipocalins by lacking the conserved disulfide bond and for being able to form the domain-swapped dimers.
Olga V. Stepanenko +5 more
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Structure and stability of recombinant bovine odorant-binding protein: III. Peculiarities of the wild type bOBP unfolding in crowded milieu [PDF]
PeerJ, 2016 Contrary to the majority of the members of the lipocalin family, which are stable monomers with the specific OBP fold (a β-barrel consisting of a 8-stranded anti-parallel β-sheet followed by a short α-helical segment, a ninth β-strand, and a disordered C-
Olga V. Stepanenko +5 more
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Structure and stability of recombinant bovine odorant-binding protein: II. Unfolding of the monomeric forms [PDF]
PeerJ, 2016 In a family of monomeric odorant-binding proteins (OBPs), bovine OBP (bOBP), that lacks conserved disulfide bond found in other OBPs, occupies unique niche because of its ability to form domain-swapped dimers.
Olga V. Stepanenko +5 more
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Biomolecules, 2023 The formation and function of membrane-less organelles (MLOs) is one of the main driving forces in the molecular life of the cell. These processes are based on the separation of biopolymers into phases regulated by multiple specific and nonspecific inter-
Sergey A. Silonov +7 more
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Spectral characteristics of the mutant form GGBP/H152C of D-glucose/D-galactose-binding protein labeled with fluorescent dye BADAN: influence of external factors [PDF]
PeerJ, 2014 The mutant form GGBP/H152C of the D-glucose/D-galactose-binding protein with the solvatochromic dye BADAN linked to cysteine residue Cys 152 can be used as a potential base for a sensitive element of glucose biosensor system.
Alexander V. Fonin +8 more
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Amyloid fibrils degradation: the pathway to recovery or aggravation of the disease?
Frontiers in Molecular Biosciences, 2023 Background: The most obvious manifestation of amyloidoses is the accumulation of amyloid fibrils as plaques in tissues and organs, which always leads to a noticeable deterioration in the patients’ condition and is the main marker of the disease. For this
Maksim I. Sulatsky +6 more
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The unfolding of iRFP713 in a crowded milieu [PDF]
PeerJ, 2019 The exploring of biological processes in vitro under conditions of macromolecular crowding is a way to achieve an understanding of how these processes occur in vivo.
Olesya V. Stepanenko +3 more
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Collagen Structure and Stability [PDF]
Annual Review of Biochemistry, 2009 Collagen is the most abundant protein in animals. This fibrous, structural protein comprises a right-handed bundle of three parallel, left-handed polyproline II-type helices. Much progress has been made in elucidating the structure of collagen triple helices and the physicochemical basis for their stability.
Matthew D, Shoulders, Ronald T, Raines
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Photophysical Properties of Fluorescent Probe Thioflavin T in Crowded Milieu
Journal of Spectroscopy, 2017 Thioflavin T (ThT) is a widely used fluorescent probe of amyloid fibrils, which accompanies many serious neurodegenerative and other diseases. Until recently, examinations of processes of amyloid fibril formation in vitro were conducted in solutions ...
Natalia P. Rodina +5 more
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