Results 41 to 50 of about 6,294,780 (309)

The Stoichiometric Interaction of the Hsp90-Sgt1-Rar1 Complex by CD and SRCD Spectroscopy

Frontiers in Molecular Biosciences, 2018
While the molecular details by which Hsp90 interacts with Sgt1 and Rar1 were previously described the exact stoichiometric complex that is formed remains elusive. Several possibilities remain that include two asymmetric complexes, Sgt12-Hsp902-Rar12 (two
Giuliano Siligardi, Minghao Zhang, Chrisostomos Prodromou   +2 more
doaj   +1 more source

Transition mechanism for a periodic bar-and-joint framework with limited degrees of freedom controlled by uniaxial load and internal stiffness [PDF]

Royal Society Open Science, 2018
A specific periodic bar-and-joint framework with limited degrees of freedom is shown to have a transition mechanism when subjected to an external force.
H. Tanaka, K. Hamada, Y. Shibutani
doaj   +1 more source

First-Principles Study of Structural Stability and Mechanical Properties of Ta–W–Hf Alloys

Metals, 2023
In order to obtain the effect of W and Hf elements on the mechanical properties of Ta–W–Hf alloys, the structural, mechanical, and electronic properties of Ta–xW–6.25Hf (x = 6.25, 12.50, 18.75, 25.00, 31.25, 50.00) alloys were studied using first ...
Xudong Ran, Shuhai Huang, Shaolan Zhou, Wei Lei, Yang Wu, Qiang Chen   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Cathepsin B prevents cell death by fragmentation and destruction of pathological amyloid fibrils

Cell Death Discovery
Amyloid fibrils cause organ and tissue dysfunction in numerous severe diseases. Despite the prevalence and severity of amyloidoses, there is still no effective and safe anti-amyloid therapy.
Maksim I. Sulatsky, Olesya V. Stepanenko, Olga V. Stepanenko, Ekaterina V. Mikhailova, Anna I. Sulatskaya   +4 more
doaj   +1 more source

A Complex Investigation of LATP Ceramic Stability and LATP+PVDF Composite Membrane Performance: The Effect of Solvent in Tape-Casting Fabrication

Membranes, 2023
Redox flow batteries (RFBs) are a prospective energy storage platform to mitigate the discrepancy between barely adjustable energy production and fluctuating demand.
Zainab Waris, Nikita O. Akhmetov, Mariam A. Pogosova, Svetlana A. Lipovskikh, Sergey V. Ryazantsev, Keith J. Stevenson   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Defining the Structural Stability Field of Disordered Fluorite Oxides

Frontiers in Chemistry, 2021
Fluorite-structured oxides constitute an important class of materials for energy technologies. Despite their high level of structural symmetry and simplicity, these materials can accommodate atomic disorder without losing crystallinity, making them ...
Eric C. O’Quinn, Devon L. Drey, Maik K. Lang   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Bioinformatics Analysis of the Actin Interactome

Proceedings
Actin is a key protein of the muscle contraction system [...]
Yakov I. Mokin, Olga I. Povarova, Iuliia A. Antifeeva, Konstantin K. Turoverov, Irina M. Kuznetsova, Alexander V. Fonin   +5 more
doaj   +1 more source