Results 211 to 220 of about 2,448,479 (335)

SVJedi-graph: genotyping close and overlapping structural variants with a variation graph and long-reads

, 2022
Sandra Romain, Claire Lemaitre
openalex   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Genome graphs reveal the importance of structural variation in Mycobacterium tuberculosis evolution and drug resistance. [PDF]

Nat Commun
Canalda-Baltrons A, Silcocks M, Hall MB, Theys D, Chang 常戌灵 X, Viberg LT, Sherry NL, Coin L, Dunstan SJ.   +8 more
europepmc   +1 more source

Analysis of Conformational Variation in Macromolecular Structural Models

, 2012
Sandeep Kumar Srivastava, Savitha Gayathri, Babu A. Manjasetty, B. Gopal   +3 more
openalex   +2 more sources

Supplementary Methods and Materials, Results, Legends for Tables 1-11 and Figures 1-3 from Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing

, 2023
Zhi Jiang Zang, Choon Kiat Ong, Ioana Cutcutache, Willie Yu, Shen Li Zhang, Dachuan Huang, Lian Dee Ler, Karl Dykema, Anna Gan, Jiong Tao, Siyu Lim, Yujing Liu, P. Andrew Futreal, Heike I. Grabsch, Kyle A. Furge, Liang Kee Goh, Steve Rozen, Bin Tean Teh, Patrick Tan   +18 more
openalex   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Substantial non-homologous recombination and structural variation results from Brassica AABC and CCAB hybrid meiosis. [PDF]

Plant J
Lv Z, Mahmoudi S, Mason AS.
europepmc   +1 more source

Representing genomic structural variation [PDF]

Nature Methods, 2012
Cydney Nielsen, Bang Wong
openaire   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Exploring cattle structural variation in the era of long reads, pangenome graphs, and near-complete assemblies. [PDF]

J Anim Sci Biotechnol
Liu GE.
europepmc   +1 more source