Results 221 to 230 of about 15,084,422 (295)

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

European ash pangenome reveals widespread structural variation and genetic basis of low ash dieback susceptibility. [PDF]

Nat Commun
Wood DP, Vatanparast M, Galanti D, Gudgeon C, Wheeler K, Curran E, Yant L, Whittet R, Nichols RA, Buggs RJA, Kelly LJ.   +10 more
europepmc   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Global impact of germline structural variation on the cancer proteome. [PDF]

Nat Commun
Chen F, Zhang Y, Paulin LF, Chandrashekar DS, Varambally S, Sedlazeck FJ, Creighton CJ.   +6 more
europepmc   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Parallel adaptation to geothermally-warmed habitats due to common structural variation and functional developmental pathways. [PDF]

Nat Commun
Brachmann MK, Costa APB, Robertson S, Smith B, Donoghue K, Pilakouta N, Whitehead M, Liu X, Kristjánsson B, Skúlason S, Selman C, Parsons K.   +11 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Detecting pathogenic structural variation in families with undiagnosed rare disease in a national genome project. [PDF]

Eur J Hum Genet
Dutta P, Pagnamenta AT, Robert C, McGuigan AEF, Ross A, Tobias ES, McGowan R, Ansari M, Baty D, Berg J, Bradley T, Cerqueira V, Diamond A, Halachev M, Lampe A, Meynert A, Newman C, Thomson M, Trivedi U, Williams N, Yu J, Santoyo-Lopez J, Miedzybrodzka Z, Taylor JC, Aitman TJ.   +24 more
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source