Results 201 to 210 of about 5,946,777 (312)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Flexible and rapid validation of structural variation using adaptive sampling. [PDF]

Eur J Hum Genet
Paivandy A, Lenner F, Eisfeldt J, Jonson T, Ehrencrona H, Lindstrand A, Scherer SW, Feuk L.   +7 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The biomedical landscape of genomic structural variation in the qatari population. [PDF]

Nat Commun
Aliyev E, Syed N, Visconti A, Aliyev T, Belkadi A, Ghorbani M, Rossi N, Naeem H, Gandhi GD, Thareja G, Al-Maraghi A, Aamer W, Ibrahim AA, Shaath R, Al-Ajli FO, Razali RM, Sedlazeck FJ, Davila S, Akil A, Suhre K, Mokrab Y, Falchi M, Fakhro KA.   +22 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

A simple method to efficiently generate structural variation in plants. [PDF]

PLoS Genet
Bechen LL, Ahsan N, Bahrainwala A, Gehring M, Satyaki PRV.   +4 more
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Pan-genome analysis reveals structural variation- associated expression and evolutionary diversity of the <i>ZmCYP450</i> gene family in maize. [PDF]

Front Plant Sci
Qi W, Wang J, Chang J, Bu H, Xiao J, Zhang N, Ren Z.   +6 more
europepmc   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Evaluating the Zero-Markup Drug Policy's Effects on Financial Burden and Pharmaceutical Channel Migration: A Structural Variation and Interrupted Time Series Analysis from Hubei, China. [PDF]

J Healthc Leadersh
Zhou Y, Lin K, Xiang L.
europepmc   +1 more source