Results 191 to 200 of about 800,936 (315)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Allelic structural variation at the NLR25-1 locus enhances defense against Pseudomonas syringae in kiwifruit. [PDF]

Genome Biol
Wu Y, Wang Y, Lin Y, Zhao M, Huo Y, Zhang T, Wang H, Zhu Y, Wang L, Zheng P, Yue J, Wang S, Liu Y.   +12 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Transposable Element-Mediated Structural Variation Drives Flower Colour Diversification in Camellia. [PDF]

Plant Biotechnol J
Fan M, Jiang H, Qu Y, Zhang Y, Li X, Wang Y.   +5 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Genomic structural variation underlies cell type-specific betacyanin variegation in Chenopodium quinoa. [PDF]

Stress Biol
Zhang Z, Wang Y, Hu X, Yu T, Feng Y, Zhang J, Zhang T, Feng G, Zhang H.   +8 more
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Multispecies pangenomes reveal a pervasive influence of population size on structural variation. [PDF]

Science
Edwards SV, Fang B, Khost D, Kolyfetis GE, Cheek RG, DeRaad DA, Chen N, Fitzpatrick JW, McCormack JE, Funk WC, Ghalambor CK, Garrison E, Guarracino A, Li H, Sackton TB.   +14 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Admixture-driven structural variation diversity and its functional implications. [PDF]

Natl Sci Rev
Lou H, Wang Y, Chai Y, Ning Z, Fu R, Lu Y, Xie B, Ma S, Pan Y, Gao Y, Lu D, Bai X, Yang Y, Mamatyusupu D, Xu S.   +14 more
europepmc   +1 more source