Results 231 to 240 of about 5,946,777 (312)

Admixture-driven structural variation diversity and its functional implications. [PDF]

Natl Sci Rev
Lou H, Wang Y, Chai Y, Ning Z, Fu R, Lu Y, Xie B, Ma S, Pan Y, Gao Y, Lu D, Bai X, Yang Y, Mamatyusupu D, Xu S.   +14 more
europepmc   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Assembly and comparative analysis of the multipartite mitochondrial genome of <i>Curcuma wenyujin</i> reveals sequence divergence, structural variation, and phylogenetic placement within Commelinales. [PDF]

Front Plant Sci
Lin Z, Sun Z, Fan R, Wang Y, Dai L, He W.   +5 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Comprehensive Analysis of Wild Rice Mitochondrial Genomes Reveals Structural Variation, Repeat Dynamics, and the Evolution of <i>orf182</i>. [PDF]

Plants (Basel)
Long W, Wang J, Luo L, Zhou L, Chen W, Luo L, Xu W, Li Y, Yan L, Cai Y, Xie H.   +10 more
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Structural variation drives enhancer hijacking via 3D genome disruption in ccRCC. [PDF]

NPJ Digit Med
Dong Y, Xia W, Yang Z, Ren L, Wang H, Zhou Y, Li Q, Chen Z, Xia Z, Zheng Y, Wang F, He N, Cheng B, Ma D, Shao W, Guo W, Wang S, Liu Z, Shen J, Qi Y, Gong X, Jin J, Xie B, Zhu G, Zhang C.   +24 more
europepmc   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Comparative mitochondrial genome analysis of Panax ginseng reveals structural variation and genetic diversity. [PDF]

Sci Rep
Xi Y, Liao X, Hu H, Guo S, Shang W, Liu S, Yang TJ, Chen S, Xu J, Dou D.   +9 more
europepmc   +1 more source