Results 241 to 250 of about 800,936 (315)

The Complete Chloroplast Genome of <i>Encyclia tampensis</i> (Orchidaceae): Structural Variation and Heterogeneous Evolutionary Dynamics in Epidendreae. [PDF]

Genes (Basel)
Liu B, Huang J, Wang Z, Li D, Yuan Z, Yao Y.   +5 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Genome-wide CG hypomethylation of the <i>Arabidopsis</i> ecotype Cvi linked to structural variation and RNAi at the <i>VIM4</i>-<i>VIM2</i> locus. [PDF]

Proc Natl Acad Sci U S A
Shin SY, Park M, Lee J, Lee S, Frost JM, Fischer RL, Choi Y, Shin C.   +7 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Structural variation, selection, and diversification of the NPIP gene family from the human pangenome. [PDF]

Cell Genom
Dishuck PC, Munson KM, Lewis AP, Dougherty ML, Underwood JG, Harvey WT, Hsieh P, Pastinen T, Eichler EE.   +8 more
europepmc   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Pangenome insights into structural variation and functional diversification of barley CCT motif genes. [PDF]

Plant Genome
Zhu Z, Stein N.
europepmc   +1 more source

Empowering Adult Learning How AI Fuels Progress Across Disciplines and Professions

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT This article examines the evolving role of artificial intelligence (AI) as a transformative cognitive partner across educational and professional fields. It explores how AI shifts attention away from routine technical tasks and toward human‐centered skills such as critical thinking, ethical decision‐making, and professional judgment.
Rachel Wlodarsky
wiley   +1 more source

Expanding biobank pharmacogenomics through machine learning calls of structural variation. [PDF]

Genetics
Vanderwerff B, Pasternak AL, Fritsche LG, Bertucci-Richter E, Patil S, Boehnke M, Zhou X, Zöllner S, Hertz DL, Zawistowski M.   +9 more
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source