Results 61 to 70 of about 2,462,103 (310)

Towards a 'canonical' agranular cortical microcircuit

Frontiers in Neuroanatomy, 2015
Based on regularities in the intrinsic microcircuitry of cortical areas, variants of a 'canonical' cortical microcircuit have been proposed and widely adopted, particularly in computational neuroscience and neuroinformatics.
Sarah F. Beul, Claus C. Hilgetag, Claus C. Hilgetag   +2 more
doaj   +1 more source

Identification of gene family members and a key structural variation reveal important roles of OVATE genes in regulating tea (Camellia sinensis) leaf development

Frontiers in Plant Science, 2022
OVATE genes are a new class of transcriptional repressors with important regulatory roles in plant growth and development. Through genome-wide analysis of the OVATE gene family of tea plants, 26 and 13 family members were identified in cultivated and ...
Yanlin An, Xiaobo Xia, Tingting Jing, Feng Zhang   +3 more
doaj   +1 more source

Basic electronic properties of iron selenide under variation of structural parameters

, 2017
Since the discovery of high-temperature superconductivity in the thin-film FeSe/SrTiO$_3$ system, iron selenide and its derivates have been intensively scrutinized.
Guterding, Daniel, Jeschke, Harald O., Valenti, Roser   +2 more
core   +1 more source

Somatic structural variation and cancer [PDF]

Briefings in Functional Genomics, 2015
With the advent of next-generation sequencing technologies, we have witnessed a rapid pace of discovery of new patterns of somatic structural variation in cancer genomes, and an attempt to figure out their underlying mechanisms. Some of these mechanisms are associated with particular cancer types, and in some cases are the main cause of the structural ...
openaire   +2 more sources

SCNVSim: somatic copy number variation and structure variation simulator [PDF]

BMC Bioinformatics, 2015
Somatically acquired structure variations (SVs) and copy number variations (CNVs) can induce genetic changes that are directly related to tumor genesis. Somatic SV/CNV detection using next-generation sequencing (NGS) data still faces major challenges introduced by tumor sample characteristics, such as ploidy, heterogeneity, and purity.
Qin, Maochun, Liu, Biao, Conroy, Jeffrey M, Morrison, Carl D, Hu, Qiang, Cheng, Yubo, Murakami, Mitsuko, Odunsi, Adekunle O, Johnson, Candace S, Wei, Lei, Liu, Song, Wang, Jianmin   +11 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Genome-wide association analyses reveal copy number variant regions associated with reproduction and disease traits in Canadian Holstein cattle

Journal of Dairy Science
: This study aimed to evaluate the impact of copy number variants (CNV) on 13 reproduction and 12 disease traits in Holstein cattle. Intensity signal files containing log R ratio and B allele frequency information from 13,730 Holstein animals genotyped ...
Hinayah Rojas de Oliveira, Tatiane C.S. Chud, Gerson A. Oliveira, Jr., Isis C. Hermisdorff, Saranya G. Narayana, Christina M. Rochus, Adrien M. Butty, Francesca Malchiodi, Paul Stothard, Filippo Miglior, Christine F. Baes, Flavio S. Schenkel   +11 more
doaj   +1 more source

Investigating chromosomal structural variations in Musa acuminate using NGS approaches : [W077] [PDF]

, 2014
Structural heterozygosity is thought to be one of the main causes of sterility in banana (Musa spp.) hybrids. These structural variations impact chromosomal segregation and recombination, limiting crossing possibilities and complicating genetic analyses.
Baurens, Franc-Christophe, Cardi, Céline, Carreel, Françoise, D'Hont, Angélique, Jenny, Christophe, Kilian, Andrzej, Martin, Guillaume, Rouard, Mathieu   +7 more
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source