Results 71 to 80 of about 15,084,422 (295)

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko, Segev Gabay, Jonathan Roth, Amit Ringel, Rina Dvir, Shlomi Constantini   +5 more
wiley   +1 more source

Structural and transduction patterns of human-specific polymorphic SVA insertions

Mobile DNA
Background SINE variable number tandem repeat Alu elements (SVAs) are a unique group of hominid-specific composite retrotransposons with highly variable internal structure.
Ashley E. Kirby, Mark Loftus, Emily C. Golba, Human Genome Structural Variation Consortium, Miriam K. Konkel   +4 more
doaj   +1 more source

Impact of Initial Treatment Setting on Survival in Relapsed Pediatric and AYA Bone Sarcomas: A Secondary Analysis of a Prospective Clinical Trial

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Outcomes in relapsed or refractory pediatric and AYA bone sarcomas remain poor, and the impact of early referral to specialized sarcoma centers on survival is unclear. Early centralization of care may improve local and systemic treatment quality, but evidence in this population is limited.
Justyna Antoniuk‐Majchrzak, Katarzyna Bilska, Tomasz Koziński, Jadwiga Węcławek‐Tompol, Dorota Sega‐Pondel, Radosław Chaber, Wanda Badowska, Katarzyna Rosłan, Hanna Koseła‐Paterczyk, Anna Raciborska   +9 more
wiley   +1 more source

Structural Variation.

, 2014
Two samples declared as structural variations and one declared as containing no structural variation. Red line plots the expected LD. Blue line plots the actual LD between the first SNP and all its neighbors. At the top, three adjacent SNPs are inspected
Ricardo Salomon-Torres (602494), Curtis P. Van Tassell (175167), Rafael Villa-Angulo (602497), Carlos Villa-Angulo (602495), Lakshmi K. Matukumalli (264865), Víctor M. Gonzalez-Vizcarra (602496)   +5 more
core   +1 more source

Impact and characterization of serial structural variations across humans and great apes

Nature Communications
Modern sequencing technology enables the systematic detection of complex structural variation (SV) across genomes. However, extensive DNA rearrangements arising through a series of mutations, a phenomenon we refer to as serial SV (sSV), remain ...
Wolfram Höps, Tobias Rausch, Michael Jendrusch, Human Genome Structural Variation Consortium (HGSVC), Jan O. Korbel, Fritz J. Sedlazeck   +5 more
doaj   +1 more source

Balancing selection on genomic deletion polymorphisms in humans

eLife, 2023
A key question in biology is why genomic variation persists in a population for extended periods. Recent studies have identified examples of genomic deletions that have remained polymorphic in the human lineage for hundreds of millennia, ostensibly owing
Alber Aqil, Leo Speidel, Pavlos Pavlidis, Omer Gokcumen   +3 more
doaj   +1 more source

Structural variation reshapes population gene expression and trait variation in 2,105 Brassica napus accessions

Nature Genetics
Although individual genomic structural variants (SVs) are known to influence gene expression and trait variation, the extent and scale of SV impact across a species remain unknown.
Yuan-Yuan Zhang, Zhiquan Yang, Yi-Zhou He, Dong-Xu Liu, Yue-Ying Liu, Congyuan Liang, Mei-Li Xie, Yupeng Jia, Qinglin Ke, Yong-Ming Zhou, Xiao-Hui Cheng, Jun-Yan Huang, Li-Jiang Liu, Yang Xiang, H. Raman, D. Kliebenstein, Sheng-Yi Liu, Qing-Yong Yang   +17 more
semanticscholar   +1 more source

Uncovering Inequities: The Role of Social Determinants of Health in Hospitalized Adolescents and Young Adults With Heavy Menstrual Bleeding

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Heavy menstrual bleeding (HMB) is a common condition among adolescents and young adults (AYAs) and is the leading cause of iron deficiency anemia (IDA) in this population. Growing evidence suggests that social determinants of health (SDOH) influence menstrual bleeding patterns, access to care, and treatment. However, no studies have
Maria Carter‐Febres, Cristina Tarango, Ashley Childress, Chunyan Liu, Evan Thomas, Jennifer Pomales, Eric S. Mullins   +6 more
wiley   +1 more source

The complete chloroplast genome sequence of Enkianthus perulatus (Miq.) C.K.Schneid. (Ericaceae)

Mitochondrial DNA. Part B. Resources
Enkianthus perulatus (Miq.) C.K.Schneid. is a popular ornamental plant in Japan, for which the chloroplast genome has not been previously reported. Its complete chloroplast genome was therefore determined, using a high-throughput sequencing technique ...
Watanabe Yoichi
doaj   +1 more source

Large-scale gene expression alterations introduced by structural variation drive morphotype diversification in Brassica oleracea

Nature Genetics
Brassica oleracea, globally cultivated for its vegetable crops, consists of very diverse morphotypes, characterized by specialized enlarged organs as harvested products. This makes B. oleracea an ideal model for studying rapid evolution and domestication.
Xing Li, Yong Wang, Cheng-Cheng Cai, J. Ji, Feng-Qing Han, Lei Zhang, Shumin Chen, Ling-Kui Zhang, Yin-Qing Yang, Qi Tang, Johan Bucher, Xueli Wang, Li-Mei Yang, M. Zhuang, Kang Zhang, H. Lv, G. Bonnema, Yang-Yong Zhang, Feng Cheng   +18 more
semanticscholar   +1 more source