Results 1 to 10 of about 871,001 (271)

Structures and Biological Activities of Alkaloids Produced by Mushrooms, a Fungal Subgroup

Biomolecules, 2022
Alkaloids are a wide family of basic N-containing natural products, whose research has revealed bioactive compounds of pharmacological interest. Studies on these compounds have focused more attention on those produced by plants, although other types of ...
Jesús G. Zorrilla, Antonio Evidente
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Inhibition of Aminoglycoside 6′-N-acetyltransferase Type Ib (AAC(6′)-Ib): Structure–Activity Relationship of Substituted Pyrrolidine Pentamine Derivatives as Inhibitors [PDF]

Biomedicines, 2021
The aminoglycoside 6′-N-acetyltransferase type Ib (AAC(6′)-Ib) is a common cause of resistance to amikacin and other aminoglycosides in Gram-negatives. Utilization of mixture-based combinatorial libraries and application of the positional scanning strategy identified an inhibitor of AAC(6′)-Ib.
Kenneth Rocha, Jesus Magallon, Craig Reeves, Kimberly Phan, Peter Vu, Crista L. Oakley-Havens, Stella Kwan, Maria Soledad Ramirez, Travis LaVoi, Haley Donow, Prem Chapagain, Radleigh Santos, Clemencia Pinilla, Marc A. Giulianotti, Marcelo E. Tolmasky   +14 more
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Structural characteristics of microbial exopolysaccharides in association with their biological activities: a review

Chemical and Biological Technologies in Agriculture, 2023
Many microbial exopolysaccharides (EPS) have been reported in the last decade, and their fermentation processes, functional properties and applications, structural characterization, and biological activities have been extensively studied.
Wei Wang, Yuhao Ju, Nan Liu, Shengbo Shi, Lujiang Hao   +4 more
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Design, Synthesis, and Bioactivity of Novel Quinazolinone Scaffolds Containing Pyrazole Carbamide Derivatives as Antifungal Agents

Current Issues in Molecular Biology, 2022
In this study, 32 novel quinazolinone-scaffold-containing pyrazole carbamide derivatives were designed and synthesized in a search for a novel fungicide against Rhizoctonia solani.
Zhiwei Lei, Jianmei Yao, Huifang Liu, Xianjin Bai, Xingsi Gao, Qiuyuan Pan, Wen Yang   +6 more
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Anti-Neurodegenerating Activity: Structure–Activity Relationship Analysis of Flavonoids

Molecules, 2023
An anti-neurodegeneration activity study was carried out for 80 flavonoid compounds. The structure–activity analysis of the structures was carried out by performing three different anti-neurodegeneration screening tests, showing that in these structures,
Gagan Preet, Ahlam Haj Hasan, Piteesha Ramlagan, Shameem Fawdar, Fabien Boulle, Marcel Jaspars   +5 more
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Structure–activity relationship-based chemical classification of highly imbalanced Tox21 datasets [PDF]

Journal of Cheminformatics, 2020
AbstractThe specificity of toxicant-target biomolecule interactions lends to the very imbalanced nature of many toxicity datasets, causing poor performance in Structure–Activity Relationship (SAR)-based chemical classification. Undersampling and oversampling are representative techniques for handling such an imbalance challenge.
Gabriel Idakwo, Sundar Thangapandian, Joseph Luttrell, Yan Li, Nan Wang, Zhaoxian Zhou, Huixiao Hong, Bei Yang, Chaoyang Zhang, Ping Gong   +9 more
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Relationship Between the Structure and Immune Activity of Components From the Active Polysaccharides APS-II of Astragali Radix by Enzymolysis of Endo α-1,4-Glucanase

Frontiers in Pharmacology, 2022
Astragali Radix polysaccharides (APSs) have a wide range of biological activities. Our preliminary experiment showed that APS-Ⅱ (10 kDa) was the main immunologically active component of APSs.
Ke Li, Ke Li, Ke Li, Ke Li, Xue-qin Li, Xue-qin Li, Xue-qin Li, Guang-xin Li, Lian-jie Cui, Lian-jie Cui, Lian-jie Cui, Xue-mei Qin, Xue-mei Qin, Xue-mei Qin, Zhen-yu Li, Zhen-yu Li, Zhen-yu Li, Yu-guang Du, Yue-tao Liu, Yue-tao Liu, Yue-tao Liu, Ai-ping Li, Ai-ping Li, Ai-ping Li, Xing-yun Zhao, Xing-yun Zhao, Xing-yun Zhao, Xin-hui Fan, Xin-hui Fan, Xin-hui Fan   +29 more
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Quantitative structure–activity relationship (QSAR) analysis of aromatic effector specificity in NtrC-like transcriptional activators from aromatic oxidizing bacteria [PDF]

FEMS Microbiology Letters, 2003
A quantitative structure-activity relationship (QSAR) approach was taken to provide mechanistic insights into the interaction between the chemical structure of inducing compounds and the transcriptional activation of aromatic monooxygenase operons among the XylR/DmpR subclass of bacterial NtrC-like transcriptional regulators. Compared to XylR and DmpR,
Park, Joonhong, Malinverni, Juliana, Adriaens, Peter, Kukor, Jerome J.   +3 more
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How Does Catalase Release Nitric Oxide? A Computational Structure–Activity Relationship Study [PDF]

Journal of Chemical Information and Modeling, 2013
Hydroxyurea (HU) is the only FDA approved medication for treating sickle cell disease in adults. The primary mechanism of action is pharmacological elevation of nitric oxide (NO) levels which induces propagation of fetal hemoglobin. HU is known to undergo redox reactions with heme based enzymes like hemoglobin and catalase to produce NO.
Vankayala, Sai Lakshmana, Hargis, Jacqueline C., Woodcock, H. Lee   +2 more
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Rapid Scanning Structure–Activity Relationships in Combinatorial Data Sets: Identification of Activity Switches [PDF]

Journal of Chemical Information and Modeling, 2013
We present a general approach to describe the structure-activity relationships (SAR) of combinatorial data sets with activity for two biological endpoints with emphasis on the rapid identification of substitutions that have a large impact on activity and selectivity.
Richard A. Houghten, Richard A. Houghten, Radleigh G. Santos, José L. Medina-Franco, Austin B. Yongye, Bruce S. Edwards, Jon R. Appel, Marc A. Giulianotti, Clemencia Pinilla, Larry A. Sklar   +9 more
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