Results 91 to 100 of about 10,109,694 (374)
Design, Synthesis and Antifungal Activity of Psoralen Derivatives
Molecules, 2017 A series of linear furanocoumarins with different substituents have been designed and synthesized. Their structures were confirmed by 1H-NMR spectroscopy, high resolution mass spectra (EI-MS), IR, and X-ray single-crystal diffraction.
Xiang Yu +5 more
doaj +1 more source
Towards Inter-character Relationship-driven Story Generation [PDF]
arXiv, 2022 In this paper, we introduce the task of modeling interpersonal relationships for story generation. For addressing this task, we propose Relationships as Latent Variables for Story Generation, (ReLiSt). ReLiSt generates stories sentence by sentence and has two major components - a relationship selector and a story continuer.
arxiv
Dissecting the Structure–Activity Relationship of Galectin–Ligand Interactions
International Journal of Molecular Sciences, 2018 Galectins are β-galactoside-binding proteins. As carbohydrate-binding proteins, they participate in intracellular trafficking, cell adhesion, and cell–cell signaling. Accumulating evidence indicates that they play a pivotal role in numerous physiological
Yi-Chen Chan +5 more
semanticscholar +1 more source
Quantum chemical properties used in structure-activity relationship studies [PDF]
, 2010 In this work we show that structure-activity relationship studies are of great importance in modern chemistry and biochemistry. In order to obtain a significant correlation, it is crucial that appropriate descriptors be employed.
ARROIO, Agnaldo +2 more
core +2 more sources
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Biotechnology & Biotechnological Equipment, 2020 Dechlorination is the key step in biological degradation of dichloromethane (DCM), which is catalyzed by the enzyme DCM dehalogenase. In this study, the detailed structure and function of DCM dehalogenase in Methylobacterium rhodesianum H13 were ...
Jianguo Ni +5 more
doaj +1 more source
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Shipin gongye ke-jiDendrobium is a traditional, valuable, and nourishing medicinal herb in China. It benefits the stomach, promotes fluid production, nourishes Yin, and clears heat. Polysaccharides are among the main active ingredients of Dendrobium.
Zhaoyong LUO +7 more
doaj +1 more source
On Exploring Undetermined Relationships for Visual Relationship Detection [PDF]
arXiv, 2019 In visual relationship detection, human-notated relationships can be regarded as determinate relationships. However, there are still large amount of unlabeled data, such as object pairs with less significant relationships or even with no relationships. We refer to these unlabeled but potentially useful data as undetermined relationships.
arxiv