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Structure-Activity Relationships

open access: bronzeJournal of Synthetic Organic Chemistry, Japan, 1960
Keijiro Takagi
openalex   +4 more sources

Structures and Biological Activities of Alkaloids Produced by Mushrooms, a Fungal Subgroup

open access: yesBiomolecules, 2022
Alkaloids are a wide family of basic N-containing natural products, whose research has revealed bioactive compounds of pharmacological interest. Studies on these compounds have focused more attention on those produced by plants, although other types of ...
Jesús G. Zorrilla, Antonio Evidente
doaj   +1 more source

Structural characteristics of microbial exopolysaccharides in association with their biological activities: a review

open access: yesChemical and Biological Technologies in Agriculture, 2023
Many microbial exopolysaccharides (EPS) have been reported in the last decade, and their fermentation processes, functional properties and applications, structural characterization, and biological activities have been extensively studied.
Wei Wang   +4 more
doaj   +1 more source

Design, Synthesis, and Bioactivity of Novel Quinazolinone Scaffolds Containing Pyrazole Carbamide Derivatives as Antifungal Agents

open access: yesCurrent Issues in Molecular Biology, 2022
In this study, 32 novel quinazolinone-scaffold-containing pyrazole carbamide derivatives were designed and synthesized in a search for a novel fungicide against Rhizoctonia solani.
Zhiwei Lei   +6 more
doaj   +1 more source

Anti-Neurodegenerating Activity: Structure–Activity Relationship Analysis of Flavonoids

open access: yesMolecules, 2023
An anti-neurodegeneration activity study was carried out for 80 flavonoid compounds. The structure–activity analysis of the structures was carried out by performing three different anti-neurodegeneration screening tests, showing that in these structures,
Gagan Preet   +5 more
doaj   +1 more source

QnrS1 structure-activity relationships [PDF]

open access: yesJournal of Antimicrobial Chemotherapy, 2014
Loop B is important for low-level quinolone resistance conferred by Qnr proteins. The role of individual amino acids within QnrS1 loop B in quinolone resistance and gyrase protection was assessed.qnrS1 and 11 qnrS1 alleles with site-directed Ala mutations in loop B were expressed in Escherichia coli BL21(DE3) and proteins were purified by affinity ...
David C. Hooper   +3 more
openaire   +3 more sources

Relationship Between the Structure and Immune Activity of Components From the Active Polysaccharides APS-II of Astragali Radix by Enzymolysis of Endo α-1,4-Glucanase

open access: yesFrontiers in Pharmacology, 2022
Astragali Radix polysaccharides (APSs) have a wide range of biological activities. Our preliminary experiment showed that APS-Ⅱ (10 kDa) was the main immunologically active component of APSs.
Ke Li   +29 more
doaj   +1 more source

Structure - Activity Relationship of Mutant KatG from INH resistant Mycobacterium tuberculosis

open access: yesJournal of Pure and Applied Microbiology, 2017
Mutation in katG gene of Mycobacterium tuberculosis encoding catalase-peroxidase that damage its enzyme activities is well associated with isoniazid (INH) resistance. The katG gene from INH resistant strain of M.
Purkan Purkan   +4 more
doaj   +1 more source

Structure-activity relationships of 3-substituted-5,5- diphenylhydantoins as potential antiproliferative and antimicrobial agents [PDF]

open access: yesJournal of the Serbian Chemical Society, 2011
A series of twelve 3-substituted-5,5-diphenylhydantoins was synthesized, including some whose anticonvulsant activities have already been reported in the literature.
Trišović Nemanja   +7 more
doaj   +1 more source

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