Results 31 to 40 of about 5,840,078 (380)
Journal of Medicinal Chemistry, 2020 Ketamine, N,N-dimethyltryptamine (DMT), and other psychoplastogens possess enormous potential as neurotherapeutics due to their ability to potently promote neuronal growth.
Lee E. Dunlap +11 more
semanticscholar +1 more source
Vitamin K catabolite inhibition of ovariectomy-induced bone loss: Structure–activity relationship considerations [PDF]
, 2014 The potential benefit of vitamin K as a therapeutic in osteoporosis is controversial and the vitamin K regimen being used clinically (45 mg/day) employs doses that are many times higher than required to ensure maximal gamma‐carboxylation of the vitamin K‐
Emery, R +5 more
core +1 more source
Structure-activity relationships of the nikkomycins [PDF]
Journal of General Microbiology, 1991 The structure-activity relationships of different nikkomycins were studied to evaluate the structural requirements for a potent chitin synthase inhibitor. We investigated the transport of the nikkomycins via the peptide transport system of the yeast Yarrowia lipolytica and determined the kinetic parameters for nikkomycin Z uptake [Km = 24 microM, Vmax =
H. Heitsch +4 more
openaire +3 more sources
Investigating the Structure–Activity Relationship of the Insecticidal Natural Product Rocaglamide
CHIMIA, 2017 The natural product Rocaglamide (1), isolated from the tree Aglaia elliptifolia, is a compelling but also challenging lead structure for crop protection.
Roger G. Hall +6 more
doaj +1 more source
A Review of the Structure—Activity Relationship of Natural and Synthetic Antimetastatic Compounds
Biomolecules, 2020 There are innumerable anticancer compounds derived from either natural or synthetic origins. Many of these compounds have been further developed through structural modifications to not only inhibit cancer cell growth but also to exert an antimetastatic ...
S. K. Liew +3 more
semanticscholar +1 more source
Structure-activity relationships of estrogens.
Environmental Health Perspectives, 1985 The last 50 years has seen an exponential rise in the published reports about estrogen action. The model to describe the early events in the mechanism of action of estrogens via the estrogen receptor is updated in this paper to incorporate some of the recent data on the subcellular localization of the receptor.
M. E. Lieberman +4 more
openaire +3 more sources
Synthesis and Fungicidal Activity of β-Carboline Alkaloids and Their Derivatives
Molecules, 2015 A series of β-Carboline derivatives were designed, synthesized, and evaluated for their fungicidal activities in this study. Several derivatives electively exhibited fungicidal activities against some fungi.
Zhibin Li +5 more
doaj +1 more source
Molecules, 2020 A series of new N-phenylacetamide derivatives containing 4-arylthiazole moieties was designed and synthesized by introducing the thiazole moiety into the amide scaffold.
Hui Lu, Xia Zhou, Lei Wang, Linhong Jin
doaj +1 more source
Design, Synthesis, and Anti-Inflammatory Activities of 12-Dehydropyxinol Derivatives
Molecules, 2023 Pyxinol skeleton is a promising framework of anti-inflammatory agents formed in the human liver from 20S-protopanaxadiol, the main active aglycone of ginsenosides. In the present study, a new series of amino acid-containing derivatives were produced from
Yunxiao Wang +9 more
doaj +1 more source
Oxidative Medicine and Cellular Longevity, 2020 This study is aimed at determining the relationship of flavonoid structures to their chemical and intracellular antioxidant activities. The antioxidant activities of 60 flavonoids were investigated by three different antioxidant assays, including 2,2 ...
Qiang Zhang +7 more
semanticscholar +1 more source